TNRC6B and AGO4

Number of citations of the paper that reports this interaction (PubMedID 19383768)
23

Data Source:
BioGRID (proximity labelling technology, pull down)

		TNRC6B	AGO4
Description		trinucleotide repeat containing adaptor 6B	argonaute RISC component 4
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytoplasm Cytosol	P-body Nucleus Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding RNA Endonuclease Activity Protein Binding MiRNA Binding
	Biological Process	Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	MRNA Catabolic Process Regulation Of Translation Synaptonemal Complex Assembly Male Meiotic Nuclear Division Male Gonad Development MiRNA Metabolic Process Regulation Of Cell Morphogenesis Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Apoptotic Process RISC Complex Assembly SiRNA-mediated Gene Silencing By MRNA Destabilization
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Breast size ( 29855537) Chronotype ( 26955885 30696823) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31015462) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Hand grip strength ( 25637336) Height ( 19570815) Immature fraction of reticulocytes ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mammographic density (dense area) ( 25342443) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Meat-related diet ( 32066663) Morning person ( 30696823) Neutrophil percentage of white cells ( 27863252) Prostate cancer ( 23065704 19117981) Pulse pressure ( 27618447 27841878 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27618447) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Uterine fibroids ( 21460842 31649266 31488892 31249589 30194396) Uterine fibroids (MTAG) ( 31488892)
Interacting Genes		4 interacting genes: AGO4 PAN3 RNF10 UBQLN4	6 interacting genes: APP G3BP2 HSPA5 RNF10 TNRC6B TRIM21
Entrez ID		23112	192670
HPRD ID		10021	09559
Ensembl ID		ENSG00000100354	ENSG00000134698
Uniprot IDs		Q9UPQ9	Q9HCK5
PDB IDs			6OON
Enriched GO Terms of Interacting Partners?		Macromolecule Catabolic Process Catabolic Process MRNA Destabilization RNA Destabilization P-body Positive Regulation Of MRNA Catabolic Process Nuclear Proteasome Complex Positive Regulation Of MRNA Metabolic Process MRNA Catabolic Process PAN Complex Negative Regulation Of Autophagosome Maturation RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability SiRNA-mediated Gene Silencing By MRNA Destabilization Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Cytosolic Proteasome Complex Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Schwann Cell Proliferation RISC-loading Complex Regulation Of Nucleobase-containing Compound Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process K48-linked Polyubiquitin Modification-dependent Protein Binding RISC Complex Assembly Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Catabolic Process Poly(A)-specific Ribonuclease Activity Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Pre-miRNA Processing Regulation Of Autophagosome Maturation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Glial Cell Proliferation MRNA Methylguanosine-cap Decapping Positive Regulation Of Myelination Positive Regulation Of RNA Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Poly(A) Binding RNA Decapping Synaptonemal Complex Assembly MiRNA Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Synaptonemal Complex Organization Positive Regulation Of Catabolic Process	Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex PTB Domain Binding Innate Immune Response Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Response To Peptide Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Cytokine Lipoprotein Particle Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Catabolic Process Cerebellum Structural Organization Proteasomal Protein Catabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Stress Granule Assembly P-body Cytoplasmic Stress Granule Protein Autoubiquitination Protein Monoubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Defense Response To Symbiont Axon Midline Choice Point Recognition Defense Response To Other Organism
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