SETX and PRRC2B

		SETX	PRRC2B
Description		senataxin	proline rich coiled-coil 2B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Nuclear Body Axon Growth Cone Cell Projection Intercellular Bridge
	Molecular Function	Nucleotide Binding Transcription Termination Site Sequence-specific DNA Binding DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	DNA Repair Double-strand Break Repair DNA Recombination DNA-templated Transcription Termination Termination Of RNA Polymerase II Transcription MRNA Splice Site Recognition RNA Processing DNA Damage Response Spermatogenesis Nervous System Development Circadian Rhythm Positive Regulation Of Neuron Projection Development Cell Differentiation Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Termination Of DNA-templated Transcription Cellular Response To Hydrogen Peroxide Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled	Cell Differentiation
Pathways
Drugs
Diseases		Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Distal hereditary motor neuropathies (dHMN)
GWAS		Current cigarettes per day in chronic obstructive pulmonary disease ( 29631575) Metabolite levels ( 23823483)	Femur bone mineral density x serum urate levels interaction ( 34046847) Lung function ( 31902109) Urate levels ( 31578528)
Interacting Genes		16 interacting genes: BCYRN1 BRCA1 CHD3 EXOSC9 HIPK2 PIAS1 PRRC2B PTEN RNF10 SUMO1 SUMO2 TDG TOPORS UBA2 UBC UBE2I	48 interacting genes: AK8 ALG13 ANKHD1 APP ATN1 ATXN1 ATXN1L BAG4 BCAS2 CFAP77 CRK CTBP1 DAPK1 DDX11 DDX31 DIMT1 DMRTB1 DNAJC5 DPY30 EHMT2 ESS2 EXOSC1 EXOSC4 EXOSC7 FBXO7 GTF3C4 IPO5 LSM5 MRPL44 NIP7 NXF1 NXF5 PLPP7 PRPF39 QKI RBFOX2 RBPMS RERE RPL13 SETX SF1 SRPK2 SRSF4 TRNAU1AP TXNL4A UCK1 YTHDF1 YTHDF3
Entrez ID		23064	84726
HPRD ID		07622	13805
Ensembl ID		ENSG00000107290	ENSG00000288701
Uniprot IDs		Q7Z333	Q5JSZ5 Q9BU62
PDB IDs
Enriched GO Terms of Interacting Partners?		PML Body Protein Sumoylation Protein Modification By Small Protein Conjugation SUMO Transferase Activity Small Protein Activating Enzyme Binding Presynaptic Cytosol Post-translational Protein Modification Postsynaptic Cytosol Protein Modification Process Protein Tag Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Macromolecule Metabolic Process PML Body Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Proteolysis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding RNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Proteolysis SUMO Binding Nucleus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Damage Response Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Macromolecule Metabolic Process XY Body Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Glutamatergic Synapse Regulation Of Macromolecule Biosynthetic Process	RNA Binding Nucleus RNA Processing RNA Metabolic Process Nucleic Acid Binding RNA Splicing MRNA Metabolic Process Nucleolus MRNA Processing MRNA Binding Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleolar Exosome (RNase Complex) Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Macromolecule Metabolic Process Regulation Of RNA Splicing Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing POZ Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress Granule Assembly Negative Regulation Of Macromolecule Metabolic Process MRNA Splice Site Recognition Exoribonuclease Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Spliceosomal Complex Nuclear RNA Export Factor Complex U4 SnRNA 3'-end Processing Protein-RNA Complex Assembly Cytoplasm Transcription Corepressor Activity Negative Regulation Of Metabolic Process Spliceosomal Complex Assembly Memory Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nuclear MRNA Surveillance Nuclear Inclusion Body N6-methyladenosine-containing RNA Reader Activity
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