PDZD2 and NRXN1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDZD2	NRXN1
Description		PDZ domain containing 2	neurexin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Centriolar Satellite	Nucleolus Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Endocytic Vesicle Neuromuscular Junction Nuclear Membrane Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body Axonal Growth Cone Synapse Protein Complex Involved In Cell-cell Adhesion Presynapse Trans-synaptic Protein Complex Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function		Transmembrane Signaling Receptor Activity Signaling Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Signaling Receptor Activity Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Cell Adhesion	Angiogenesis Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Adult Behavior Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Social Behavior Protein Localization To Synapse Vocal Learning Positive Regulation Of CAMP-mediated Signaling Establishment Of Protein Localization Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Vocalization Behavior Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering NMDA Glutamate Receptor Clustering Gephyrin Clustering Involved In Postsynaptic Density Assembly Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Neuromuscular Synaptic Transmission Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Neurexins and neuroligins Neurexins and neuroligins Non-integrin membrane-ECM interactions Neurexins and neuroligins Neurexins and neuroligins
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Chronic obstructive pulmonary disease ( 29394082) Corpus callosum central volume ( 31530798) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) Myocardial infarction ( 26708285) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Renal cell carcinoma ( 23184150) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Reticulocyte fraction of red cells ( 32888494) Self-reported childhood asthma in adult smokers ( 30373671) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Weight ( 34074324) Working memory ( 31598132)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Body mass index ( 28892062) Chromosomal aberration frequency (chromatid type) ( 31586183) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Educational attainment ( 25201988) General risk tolerance (MTAG) ( 30643258) Isovolumetric relaxation time ( 28394258) Lateral ventricle temporal horn volume ( 31530798) Longevity ( 20834067) Lung cancer in ever smokers ( 28604730) Metabolite levels (HVA/MHPG ratio) ( 23319000) Morning person ( 30696823) Nicotine dependence symptom count ( 25555482) Personality dimensions ( 20691247) Post bronchodilator FEV1/FVC ratio ( 26634245) Recurrent major depressive disorder ( 34099189) Refractive astigmatism ( 25367360) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Severe gingival inflammation ( 28459102) Smoking initiation ( 33082346) Systolic blood pressure ( 30578418 30224653) Temperament ( 22832960) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32203549) Word spelling ( 30741946)
Interacting Genes		5 interacting genes: ADGRB1 CST3 CTNND2 NRXN1 PKP4	29 interacting genes: AFDN APBA1 APBA2 ATP13A2 CASK MACF1 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A RTN4 SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3
Entrez ID		23037	9378
HPRD ID		10142	11858
Ensembl ID		ENSG00000133401	ENSG00000179915
Uniprot IDs		O15018	A0A0D9SEM5 A0A0D9SEQ7 A0A1D5RMU6 E7EQN4 H0Y568 H7BYC7 P58400 Q9ULB1
PDB IDs			3B3Q 5Z8Y 6NID
Enriched GO Terms of Interacting Partners?		Cell Projection Morphogenesis Postsynaptic Density Cell Adhesion Neuron Projection Morphogenesis Positive Regulation Of Synapse Assembly Anchoring Junction Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Cell-cell Adhesion Cell Junction Organization Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Cell Junction Assembly Negative Regulation Of Protein Catabolic Process Negative Regulation Of Blood Vessel Remodeling Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Regulation Of Synapse Assembly Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Transmembrane Signaling Receptor Activity Engulfment Of Apoptotic Cell Cell-cell Junction Cell Junction Plasma Membrane Vesicle Regulation Of Collagen Catabolic Process Adherens Junction Negative Regulation Of Filopodium Assembly Cerebellar Granule Cell Differentiation Postsynaptic Density Protein 95 Clustering Neuronal Signal Transduction NMDA Selective Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Trans-synaptic Protein Complex Gephyrin Clustering Involved In Postsynaptic Density Assembly AMPA Selective Glutamate Receptor Signaling Pathway Neuroligin Family Protein Binding Type 1 Fibroblast Growth Factor Receptor Binding Postsynaptic Membrane Assembly Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Junction Assembly Cell Projection Organization Synapse Organization Cell Junction Assembly Vocal Learning	Exocytic Vesicle Calcium-dependent Activation Of Synaptic Vesicle Fusion Calcium-dependent Phospholipid Binding Calcium Ion Sensor Activity Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Calcium Ion-dependent Exocytosis Neurexin Family Protein Binding Regulation Of Regulated Secretory Pathway Regulation Of Exocytosis Modulation Of Chemical Synaptic Transmission Dense Core Granule Regulation Of Vesicle Fusion SNARE Binding Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Exocytosis Regulation Of Secretion By Cell Regulation Of Secretion Plasma Membrane Regulation Of Vesicle-mediated Transport Phosphatidylinositol-4,5-bisphosphate Binding Synapse Regulation Of Neurotransmitter Secretion Positive Regulation Of Transport Positive Regulation Of Exocytosis Secretion By Cell Vesicle-mediated Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Regulated Secretory Pathway Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Secretion Positive Regulation Of Cellular Component Organization Postsynaptic Membrane Assembly Excitatory Synapse Neuron To Neuron Synapse Clathrin Binding Cellular Localization Postsynaptic Membrane Organization Presynaptic Membrane Assembly Cell-cell Signaling Positive Regulation Of Secretion By Cell Presynaptic Membrane Organization Regulation Of Transport Signaling Cytoplasmic Vesicle Positive Regulation Of Secretion Cell Communication Exocytosis
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