TMCC1 and ACAD9

		TMCC1	ACAD9
Description		transmembrane and coiled-coil domain family 1	acyl-CoA dehydrogenase family member 9
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Endomembrane System Membrane Endoplasmic Reticulum-endosome Membrane Contact Site	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Dendrite Mitochondrial Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity
	Biological Process	Endoplasmic Reticulum Organization Endosomal Transport Membrane Fission Endosome Membrane Tubulation Endosome Fission	Long-chain Fatty Acid Metabolic Process Fatty Acid Metabolic Process Mitochondrial Respiratory Chain Complex I Assembly Medium-chain Fatty Acid Metabolic Process
Pathways			Complex I biogenesis
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		A body shape index ( 34021172) Breast size ( 22747683) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Type 2 diabetes ( 30297969) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Dental caries ( 23064961) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		5 interacting genes: ACAD9 APP PLXND1 RAB7A ZDHHC17	5 interacting genes: H1-10 HMCES ISY1 SEC61A1 TMCC1
Entrez ID		23023	28976
HPRD ID		15518	12412
Ensembl ID		ENSG00000172765	ENSG00000177646
Uniprot IDs		A0A8V8TLJ9 E9PC87 O94876 Q6N039	Q9H845 Q9H9W4
PDB IDs			8PHE 8PHF
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Cell Recognition Cell Body Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Neuron Recognition Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Lipophagy Glutamatergic Synapse Synaptic Vesicle Recycling Via Endosome Synaptic Target Recognition Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Medium-chain Fatty Acyl-CoA Dehydrogenase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Cytoplasmic Vesicle Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Mitochondrial Membrane Negative Regulation Of Exosomal Secretion Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Long-chain Fatty Acyl-CoA Dehydrogenase Activity Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Protein To Membrane Docking Regulation Of Endosome Organization	Endoplasmic Reticulum Organization Pronephric Nephron Development Protein-DNA Covalent Cross-linking Activity Post-spliceosomal Complex Regulation Of DNA Recombination DNA-(abasic Site) Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Endosome Fission Endosome Membrane Tubulation Endoplasmic Reticulum-endosome Membrane Contact Site Signal Sequence Binding Membrane Tubulation Sec61 Translocon Complex MRNA 3'-splice Site Recognition SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Protein-DNA Covalent Cross-linking Repair Post-mRNA Release Spliceosomal Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining SRP-dependent Cotranslational Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nephron Development Somatic Hypermutation Of Immunoglobulin Genes DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Prp19 Complex U2-type Catalytic Step 1 Spliceosome Cotranslational Protein Targeting To Membrane
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