NINL and RIBC2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NINL	RIBC2
Description		ninein like	RIB43A domain with coiled-coils 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule	Nucleus Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Microtubule Anchoring At Centrosome	Flagellated Sperm Motility
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Telomere length ( 30185882) Urate levels ( 31578528)	Waist circumference ( 28552196) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		55 interacting genes: AKAP17A APEX2 APMAP AURKB CBY2 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA ERBB2 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 POLR3F PRPF18 PRPF3 RBM41 RCOR3 RGS2 RIBC2 RNF40 SEC23B SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSC1 TSPYL4 UTP14A YJU2B ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646	23 interacting genes: AP2B1 BEGAIN CCDC85B EFEMP2 GFAP GTPBP3 HOOK2 JUP KRT15 MTUS2 NINL NRBP1 PJA1 RAD54B RPL18A SARAF TEX11 TRAF2 TREX1 TRIM23 TRIM37 USHBP1 VIM
Entrez ID		22981	26150
HPRD ID		11120	11493
Ensembl ID		ENSG00000101004	ENSG00000128408
Uniprot IDs		Q9Y2I6	Q9H4K1
PDB IDs			7UNG 8J07
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Pole Nucleus Protein Binding Chromosome, Centromeric Region Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Pole Regulation Of Metaphase Plate Congression Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone Acetyltransferase Complex Positive Regulation Of Chromosome Segregation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone H4K16 Acetyltransferase Activity Spindle Microtubule Protein Localization To Chromosome Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cytoskeleton Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Negative Regulation Of Cell Cycle Phase Transition Zinc Ion Binding Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation RNA Splicing Centrosome	Intermediate Filament Organization Astrocyte Development Intermediate Filament Intermediate Filament-based Process Bergmann Glial Cell Differentiation Intermediate Filament Cytoskeleton Organization Protein Homodimerization Activity Cytoplasmic Side Of Plasma Membrane Structural Constituent Of Cytoskeleton Cytoskeleton Supramolecular Fiber Organization Blood Vessel Development Aorta Development Ubiquitin Protein Ligase Activity Astrocyte Differentiation Gamma-catenin-TCF7L2 Complex Tumor Necrosis Factor Receptor Binding TORC2 Complex Disassembly Determination Of Adult Lifespan Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Reciprocal Meiotic Recombination Homologous Recombination Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Meiotic Gene Conversion Evoked Excitatory Postsynaptic Potential
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