ELL2 and CASK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ELL2	CASK
Description		elongation factor for RNA polymerase II 2	calcium/calmodulin dependent serine protein kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex	Basement Membrane Nucleus Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Nuclear Matrix Cell Junction Vesicle Presynaptic Membrane Synapse Ciliary Membrane Cell Periphery Schaffer Collateral - CA1 Synapse
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding Protein Binding	Nucleotide Binding GMP Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Neurexin Family Protein Binding Protein Serine Kinase Activity
	Biological Process	Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II	Negative Regulation Of Cell-matrix Adhesion Cell Adhesion Intracellular Protein Localization Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Regulation Of Neurotransmitter Secretion Establishment Of Localization In Cell Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs			Formic acid Fostamatinib
Diseases			FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Albumin-globulin ratio ( 29403010) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Body mass index ( 26426971) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) IgA levels ( 28628107) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Mean corpuscular hemoglobin ( 32888494) Multiple myeloma ( 26007630 33875642) Multiple myeloma and monoclonal gammopathy ( 26007630) Non-albumin protein levels ( 29403010) Serum total protein levels ( 23022100) Telomere length ( 30185882)
Interacting Genes		7 interacting genes: AQP2 CASK EAF1 EXOC8 PRKAB2 RNF181 SIAH1	90 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L CADM1 CASKIN1 CDK9 CIMIP1 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A RSPH1 SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TIAM1 TRIM22 TSPYL2 UBC WHRN WNT7B YWHAE
Entrez ID		22936	8573
HPRD ID		11798	02164
Ensembl ID		ENSG00000118985	ENSG00000147044
Uniprot IDs		O00472 Q59FW6	A0A2R8YE77 A0A2U3TZM1 A0A7I2RJN6 O14936
PDB IDs		2E5N 5JW9 7OKX 7OKY	1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH 7OAI 7OAJ 7OAK 7OAL
Enriched GO Terms of Interacting Partners?			Neuroligin Family Protein Binding Glutamatergic Synapse PDZ Domain Binding Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Cell Projection Microtubule-based Process Intracellular Protein Localization Regulation Of Membrane Potential Positive Regulation Of Cellular Component Biogenesis Vocalization Behavior Neurotransmitter Secretion Learning Cellular Component Assembly Protein Localization To Cell Junction Social Behavior Cell Adhesion Presynaptic Membrane Microtubule Cytoskeleton Organization Protein Localization To Synapse Regulation Of Cytoskeleton Organization Cytoskeleton Organization Chemical Synaptic Transmission Neurotransmitter Transport Regulation Of System Process Cell-cell Junction Regulation Of Transport MPP7-DLG1-LIN7 Complex Trans-synaptic Signaling Learning Or Memory Regulation Of Monoatomic Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Exosomal Secretion Regulation Of Multicellular Organismal Process Voltage-gated Potassium Channel Complex Postsynaptic Membrane Plasma Membrane Neuromuscular Junction Presynapse Protein Kinase Binding Regulation Of Biological Quality Bicellular Tight Junction Protein Localization To Membrane
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