SIRT2 and FZR1

Number of citations of the paper that reports this interaction (PubMedID 22014574)
67

Data Source:
BioGRID (enzymatic study)

		SIRT2	FZR1
Description		sirtuin 2	fizzy and cell division cycle 20 related 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Heterochromatin Nucleus Chromatin Silencing Complex Chromosome Nucleolus Cytoplasm Mitochondrion Centrosome Centriole Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Membrane Growth Cone Midbody Paranodal Junction Paranode Region Of Axon Cell Projection Perikaryon Myelin Sheath Lateral Loop Schmidt-Lanterman Incisure Juxtaparanode Region Of Axon Perinuclear Region Of Cytoplasm Mitotic Spindle Meiotic Spindle Glial Cell Projection	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Chromatin Binding NAD+ Poly-ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Transferase Activity Histone Deacetylase Activity, NAD-dependent Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Histone Acetyltransferase Binding Histone Deacetylase Binding Tubulin Deacetylase Activity Ubiquitin Binding Metal Ion Binding Histone H4K16 Deacetylase Activity, NAD-dependent NAD Binding NAD+ Binding DNA-binding Transcription Factor Binding NAD-dependent Protein Demyristoylase Activity NAD-dependent Protein Depalmitoylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Immune System Process Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Mitotic Nuclear Membrane Reassembly Regulation Of Exit From Mitosis Nervous System Development Negative Regulation Of Autophagy Negative Regulation Of Peptidyl-threonine Phosphorylation Skeletal Muscle Satellite Cell Differentiation Lipid Catabolic Process Substantia Nigra Development Myelination In Peripheral Nervous System Cell Differentiation Heterochromatin Formation Subtelomeric Heterochromatin Formation Regulation Of Myelination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Peptidyl-lysine Deacetylation Epigenetic Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Regulation Of Phosphorylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Binding Post-translational Protein Modification NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Biosynthetic Process Negative Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cell Division Meiotic Cell Cycle Regulation Of Cell Cycle Response To Redox State Positive Regulation Of Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Caloric Restriction Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Hypoxia Cellular Response To Epinephrine Stimulus Tubulin Deacetylation Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Oocyte Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Reactive Oxygen Species Metabolic Process	DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Thymidine Biosynthetic Process Cell Division Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cellular Senescence
Pathways		Initiation of Nuclear Envelope (NE) Reformation	Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Cambinol
Diseases
GWAS			Red cell distribution width ( 32888494)
Interacting Genes		23 interacting genes: ARHGDIA ATRIP CDC14B CDC20 CDK2 EP300 FZR1 H3C1 HDAC6 HIF1A HOXA10 KAT2A KAT2B MCL1 MDM2 MORC2 OXTR PHGDH PLA2G4A RAD51 SP140 TUBA4A XPO1	95 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC7 ANLN ARNT BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNA1 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L DTYMK E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A ID2 KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RB1 RBBP8 SASS6 SENP2 SIRT1 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TBK1 TEAD2 TERT THRSP TK1 TTF2 UBC UBE2D1 UBE2D3 UBE2K UHRF1 USP10
Entrez ID		22933	51343
HPRD ID		10377	04687
Ensembl ID		ENSG00000068903	ENSG00000105325
Uniprot IDs		A0A0A0MRF5 Q8IXJ6	Q9UM11
PDB IDs		1J8F 3ZGO 3ZGV 4L3O 4R8M 4RMG 4RMH 4RMI 4RMJ 4X3O 4X3P 4Y6L 4Y6O 4Y6Q 5D7O 5D7P 5D7Q 5DY4 5DY5 5FYQ 5G4C 5MAR 5MAT 5Y0Z 5Y5N 5YQL 5YQM 5YQN 5YQO 6L65 6L66 6L71 6L72 6NR0 6QCN 7BOS 7BOT 8OWZ 8PY3 8QOO 8QT0 8QT1 8QT2 8QT3 8QT4 8QT8 8QTU 8TGP 8XE7	4UI9 5L9T 5L9U 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Process Histone Deacetylase Binding Negative Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Cellular Response To Stress Negative Regulation Of Cell Cycle Internal Protein Amino Acid Acetylation Nucleoplasm Protein-containing Complex Regulation Of Metabolic Process DNA Damage Response Regulation Of Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Peptidyl-lysine Acetylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Histone H3K9 Acetyltransferase Activity Acetyltransferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Histone Acetyltransferase Complex Regulation Of Cellular Response To Stress Protein-lysine-acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis DNA Damage Checkpoint Signaling Histone Acetyltransferase Activity Nucleus Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Protein Acetylation Chromatin Remodeling Small Molecule Biosynthetic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Monocarboxylic Acid Metabolic Process Epigenetic Regulation Of Gene Expression Cytosol Negative Regulation Of Centriole Replication Regulation Of Centrosome Duplication Intracellular Signal Transduction Response To Stress Gluconeogenesis Regulation Of Gluconeogenesis	Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Nucleus Regulation Of Primary Metabolic Process Cytoplasm Regulation Of Chromosome Segregation Cytosol Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Regulation Of Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Spindle Protein Kinase Activity Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Cell Population Proliferation Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Transferase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process
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