RAB18 and UCN

		RAB18	UCN
Description		RAB18, member RAS oncogene family	urocortin
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Secretory Granule Membrane Cis-Golgi Network Membrane Endoplasmic Reticulum Tubular Network	Extracellular Region Axon Dendrite Neuronal Cell Body Varicosity Perikaryon Axon Terminus
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding	G Protein-coupled Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Eye Development Intracellular Protein Transport Small GTPase-mediated Signal Transduction Brain Development Protein Transport Lipid Droplet Organization Endoplasmic Reticulum Tubular Network Organization	Startle Response Response To Oxidative Stress G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Learning Or Memory Feeding Behavior Associative Learning Aerobic Respiration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Auditory Stimulus Positive Regulation Of Cell Growth Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Social Behavior Vasodilation Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Positive Regulation Of Calcium Ion Import Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response
Pathways		Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Class B/2 (Secretin family receptors) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases		Warburg micro syndrome
GWAS		A body shape index ( 34021172) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ear infection ( 27182965 28928442) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Crohn's disease ( 23128233)
Interacting Genes		16 interacting genes: APBB1IP AQP6 CHM COPS4 DVL3 ELOVL4 ERRFI1 FAM107A PDE6D PPP2R1A PPP2R1B PRTFDC1 TAX1BP1 TOM1L1 TREH UCN	5 interacting genes: CRHBP CRHR1 CRHR2 LEP RAB18
Entrez ID		22931	7349
HPRD ID		03731	02970
Ensembl ID		ENSG00000099246	ENSG00000163794
Uniprot IDs		B7Z4P9 Q9NP72	P55089
PDB IDs		1X3S	2RMF 3N96 6PB0 6PB1 7TRY 7TS0
Enriched GO Terms of Interacting Partners?		Meiotic Sister Chromatid Cohesion, Centromeric Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Autophosphorylation Protein Phosphatase Type 2A Complex Small GTPase Binding Response To Glucocorticoid Response To Corticosteroid Nitrate Transmembrane Transporter Activity Meiotic Spindle Elongation Sister Chromatid Cohesion Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Phosphatase Regulator Activity Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Response To Steroid Hormone Trehalose Metabolic Process Trehalose Catabolic Process Alpha,alpha-trehalase Activity	Cellular Response To Peptide Hormone Stimulus Corticotropin-releasing Hormone Binding Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Corticotropin-releasing Hormone Stimulus Female Pregnancy Behavioral Response To Ethanol Hormone-mediated Signaling Pathway Adult Behavior Response To Hormone Cellular Response To Oxygen-containing Compound Regulation Of Hormone Secretion G Protein-coupled Peptide Receptor Activity Negative Regulation Of Peptide Secretion Axon Terminus Secretion By Cell Negative Regulation Of Transport Negative Regulation Of Hormone Secretion Peptide Hormone Secretion Peptide Secretion Negative Regulation Of Corticotropin Secretion Secretion Regulation Of Transmembrane Transporter Activity Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Secondary Lysosome Regulation Of Hormone Levels Regulation Of Monoatomic Ion Transmembrane Transporter Activity Hormone Secretion Activation Of Protein Kinase C Activity Positive Regulation Of Fat Cell Apoptotic Process Cellular Response To L-ascorbic Acid Negative Regulation Of Glutamine Transport Peptide Transport Regulation Of System Process Regulation Of Secretion By Cell Hormone Transport Response To Estradiol Negative Regulation Of Transmembrane Transport Regulation Of Secretion Corticotropin Secretion Regulation Of Lipoprotein Lipid Oxidation Regulation Of Fat Cell Apoptotic Process Amide Transport Negative Regulation Of Secretion By Cell Negative Regulation Of Glucagon Secretion Signal Release Signal Transduction Negative Regulation Of Secretion
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