KIFAP3 and RAP1GDS1

Number of citations of the paper that reports this interaction (PubMedID 8900189)
0

Data Source:
BioGRID (pull down, two hybrid)
HPRD (two hybrid, in vitro)

		KIFAP3	RAP1GDS1
Description		kinesin associated protein 3	Rap1 GTPase-GDP dissociation stimulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Photoreceptor Outer Segment Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Kinesin Complex Spindle Microtubule Cilium Axoneme Microtubule Cytoskeleton Kinesin II Complex Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Transition Zone Ciliary Basal Body Ciliary Tip Postsynapse Glutamatergic Synapse Periciliary Membrane Compartment	Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Kinesin Binding Protein Phosphatase Binding Intraciliary Transport Particle B Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Apoptotic Process Microtubule-based Process Microtubule-based Movement Signal Transduction Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Cell Population Proliferation Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Apoptotic Process Cilium Organization Positive Regulation Of Calcium-dependent Cell-cell Adhesion Protein-containing Complex Assembly Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex	Cardiac Muscle Hypertrophy Regulation Of Mitochondrion Organization Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Protein Localization To Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of ERK5 Cascade CAAX-box Protein Maturation Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Matrix Metallopeptidase Secretion
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins	RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Adverse response to drug ( 30420678) Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 28416818) L-selectin levels ( 25576479) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		34 interacting genes: APC AR C19orf44 CCSER2 DHX37 DISC1 GTSE1 HOXB5 KANK2 KIF3B MAP3K10 MAP3K11 MARK2 MEST MINK1 MOS MYPOP NAA10 NAA11 NAV1 NCF2 NIPSNAP3A NUDT21 PARD6G PEX19 PRNP RAP1GDS1 RBFOX1 RBM14 RPGR RTP5 SMC3 SRC TOR1AIP1	27 interacting genes: ABCB7 AKT1 ANTXR2 CDC42 DIRAS1 DOC2A EGFR HRAS KIFAP3 KRAS LCOR LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAC1 RAP1A RAP2B RHOA RNF19B RRAS2 UBC ZNF451
Entrez ID		22920	5910
HPRD ID		03499	11763
Ensembl ID		ENSG00000075945	ENSG00000138698
Uniprot IDs		A0AAQ5BGI3 Q92845	B3KNU0 P52306 Q6U7G8
PDB IDs			5XGC 5ZHX
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Protein Autophosphorylation Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Cytoplasm Organelle Organization MAP Kinase Kinase Kinase Activity Protein N-terminal-serine Acetyltransferase Activity Cytoskeleton Organization ATPase Binding Microtubule Cytoskeleton Organization NatA Complex Microtubule Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity MAPK Cascade Regulation Of Protein Serine/threonine Kinase Activity Microtubule Binding Microtubule Cytoskeleton JUN Kinase Kinase Kinase Activity Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Centrosome Positive Regulation Of MAPK Cascade JNK Cascade Positive Regulation Of JUN Kinase Activity N-terminal Protein Amino Acid Acetylation Regulation Of MAPK Cascade Protein Binding Cytoskeleton Organelle Assembly Protein Kinase Activity Intracellular Signal Transduction Lamin Binding Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Angiotensin-activated Signaling Pathway Dynein Complex Binding Mitochondrial Calcium Ion Homeostasis Phosphorylation Protein Serine/threonine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity ATP Binding Kinase Activity Regulation Of Chromosome Organization	G Protein Activity GTPase Activity GDP Binding GTP Binding Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Glutamatergic Synapse Regulation Of Protein Localization To Membrane Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Regulation Of Locomotion Positive Regulation Of Locomotion Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Phosphorylation Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ras Protein Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Positive Regulation Of Epithelial Cell Proliferation Cerebral Cortex Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Modification Process Regulation Of Developmental Process Postsynapse Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Forebrain Radial Glial Cell Differentiation Cell Development Telencephalon Cell Migration Focal Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Positive Regulation Of Cell Cycle Process Cell Migration Forebrain Cell Migration
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