KLRK1 and HCST

Number of citations of the paper that reports this interaction (PubMedID 10426994)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		KLRK1	HCST
Description		killer cell lectin like receptor K1	hematopoietic cell signal transducer
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Carbohydrate Binding MHC Class Ib Receptor Activity Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol 3-kinase Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Immune System Process Nitric Oxide Biosynthetic Process Signal Transduction Natural Killer Cell Activation Cell Differentiation T Cell Costimulation Positive Regulation Of Type II Interferon Production Negative Regulation Of GTPase Activity Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Defense Response To Gram-positive Bacterium Positive Regulation Of Multicellular Organismal Process Cellular Response To Lipopolysaccharide Defense Response To Other Organism Negative Regulation Of Natural Killer Cell Chemotaxis	Protein Phosphorylation Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Interleukin-1-receptor antagonist levels ( 22205395) Obesity-related traits ( 23251661) Psoriasis ( 28537254)
Interacting Genes		8 interacting genes: HCST MICB PDE4C RAE1 RAET1E RAET1G TYROBP ULBP3	6 interacting genes: KLRK1 PIK3R1 SEC22A SPOP STARD3NL VSTM1
Entrez ID		22914	10870
HPRD ID		17240	04971
Ensembl ID		ENSG00000213809	ENSG00000126264
Uniprot IDs		P26718	Q9UBK5
PDB IDs		1HYR 1KCG 1MPU 4PDC 4S0U 8TM0 8TM2 9DH2
Enriched GO Terms of Interacting Partners?		Natural Killer Cell Lectin-like Receptor Binding Natural Killer Cell Mediated Immunity Lymphocyte Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Cell Killing Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Immune Effector Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response Regulation Of T Cell Mediated Cytotoxicity Immune Response Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Immune Effector Process Innate Immune Response Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Immune Response Defense Response To Symbiont Defense Response To Other Organism Antigen Processing And Presentation External Side Of Plasma Membrane Regulation Of T Cell Mediated Immunity Regulation Of Immune System Process Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Immune System Process Immune System Process Response To Other Organism Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Response To External Biotic Stimulus Positive Regulation Of Natural Killer Cell Mediated Immunity Defense Response Extracellular Space Positive Regulation Of Innate Immune Response Regulation Of Defense Response Regulation Of Natural Killer Cell Mediated Immunity Response To Stress Regulation Of Innate Immune Response Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway	Natural Killer Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity
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