CARD8 and CARD16

Number of citations of the paper that reports this interaction (PubMedID 11821383)
0

Data Source:
HPRD (in vitro, in vivo)

		CARD8	CARD16
Description		caspase recruitment domain family member 8	caspase recruitment domain family member 16
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Canonical Inflammasome Complex NLRP3 Inflammasome Complex CARD8 Inflammasome Complex	Protein-containing Complex Protease Inhibitor Complex
	Molecular Function	Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity	Cysteine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Kinase Binding Peptidase Inhibitor Activity Identical Protein Binding CARD Domain Binding Caspase Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Proteolysis Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response CARD8 Inflammasome Complex Assembly Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Proteolysis Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Protein Binding Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide
Pathways		Formation of apoptosome Regulation of the apoptosome activity
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3	5 interacting genes: CARD17P CARD8 CASP1 RIPK2 UBC
Entrez ID		22900	114769
HPRD ID		16425	16740
Ensembl ID		ENSG00000105483	ENSG00000204397
Uniprot IDs		Q9Y2G2	Q5EG05
PDB IDs		4IKM 6K9F 6XKJ 7JKQ 7JN7
Enriched GO Terms of Interacting Partners?		Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Cysteine-type Endopeptidase Activity CARD Domain Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Protease Inhibitor Complex Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Negative Regulation Of Interleukin-1 Production Regulation Of Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-1 Production Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Response To External Biotic Stimulus Positive Regulation Of Interleukin-18 Production Regulation Of Canonical NF-kappaB Signal Transduction Response To Molecule Of Bacterial Origin Protein-containing Complex Caspase Binding Regulation Of Interleukin-18 Production Canonical Inflammasome Complex Interleukin-18-mediated Signaling Pathway Regulation Of Cytokine Production Apoptotic Process Cell Death Programmed Cell Death Cellular Response To Lipid Identical Protein Binding Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Binding Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Intracellular Signal Transduction Cysteine-type Endopeptidase Inhibitor Activity Regulation Of Signal Transduction Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Pyroptotic Inflammatory Response Regulation Of Gene Expression Regulation Of Protein Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Osmotic Stress Defense Response	CARD Domain Binding Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production NLRP3 Inflammasome Complex Caspase Binding Canonical Inflammasome Complex Pyroptotic Cell Death Cellular Response To Lipopolysaccharide Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Activation Of Innate Immune Response Protein-containing Complex Regulation Of Cytokine Production Negative Regulation Of Interleukin-1 Beta Production Response To Lipopolysaccharide Positive Regulation Of Innate Immune Response Negative Regulation Of Interleukin-1 Production Pyroptotic Inflammatory Response Regulation Of Canonical NF-kappaB Signal Transduction Response To Molecule Of Bacterial Origin Proteolysis Positive Regulation Of Cytokine-mediated Signaling Pathway Activation Of Immune Response Cysteine-type Endopeptidase Activity Protein Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To External Biotic Stimulus Positive Regulation Of Response To Cytokine Stimulus Regulation Of Innate Immune Response Positive Regulation Of Defense Response Cellular Response To Lipid Regulation Of Apoptotic Process Positive Regulation Of Cytokine Production Regulation Of Programmed Cell Death Endopeptidase Activity Inflammatory Response CARD8 Inflammasome Complex Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune Response AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex NACHT Domain Binding AIM2 Inflammasome Complex IPAF Inflammasome Complex Response To Interleukin-18 Pattern Recognition Receptor Signaling Pathway Response To Lipid Positive Regulation Of Inflammatory Response
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