FKBP4 and GLMN

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		FKBP4	GLMN
Description		FKBP prolyl isomerase 4	glomulin, FKBP associated protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Microtubule Axon Protein-containing Complex Cell Projection Neuronal Cell Body Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding ATP Binding GTP Binding FK506 Binding Isomerase Activity Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Copper-dependent Protein Binding Nuclear Glucocorticoid Receptor Binding Tau Protein Binding Phosphoprotein Binding	Signaling Receptor Binding Hepatocyte Growth Factor Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Inhibitor Activity
	Biological Process	Protein Folding Steroid Hormone Receptor Complex Assembly Copper Ion Transport Embryo Implantation Negative Regulation Of Neuron Projection Development Androgen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Protein-containing Complex Localization Male Sex Differentiation Reproductive Structure Development	Vasculogenesis Positive Regulation Of Cytokine Production Neural Tube Closure Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Epigenetic Regulation Of Gene Expression Negative Regulation Of T Cell Proliferation Positive Regulation Of Phosphorylation Muscle Cell Differentiation Circulatory System Development
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Apolipoprotein A1 levels ( 32203549) Estradiol levels ( 34255042) FEV1 ( 30804560) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Quantitative traits ( 19197348) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252)
Interacting Genes		25 interacting genes: ACVR1 AHSA1 ATOX1 CALM1 CEBPA CSNK2A1 EGFR ESR1 FES FKBP1A GLMN HSF1 HSPA4 IL2RA IRF4 NR3C1 NR3C2 OGT PHYH PTPN2 S100A1 S100A2 S100A6 SH3BP4 SMURF2	17 interacting genes: BIRC2 BIRC3 EFS FBXW7 FKBP1A FKBP4 HSPB1 MET NSFL1C OGT PEX5 PPDPF PRDM16 RBX1 RNF7 SKP1 SNAI1
Entrez ID		2288	11146
HPRD ID		11794	03451
Ensembl ID		ENSG00000004478	ENSG00000174842
Uniprot IDs		Q02790	B4DJ85 Q92990
PDB IDs		1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY 4TW8 6RCY 8FFV	4F52
Enriched GO Terms of Interacting Partners?		STAT Family Protein Binding Hsp90 Protein Binding Estrogen Response Element Binding Regulation Of Multicellular Organismal Process Signal Transduction ATPase Binding Cytosol Calcium-dependent Protein Binding Protein-containing Complex Regulation Of Cell Population Proliferation Embryonic Placenta Development TBP-class Protein Binding Steroid Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Identical Protein Binding Intracellular Signal Transduction Cellular Response To Estradiol Stimulus Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Hemopoiesis Positive Regulation Of Signal Transduction Sequence-specific DNA Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Response To Nutrient Nuclear Receptor Activity Regulation Of Gluconeogenesis Positive Regulation Of Fibroblast Proliferation Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Lipid Binding Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway S100 Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Hormone	Regulation Of Programmed Cell Death Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Necroptotic Process Regulation Of Post-translational Protein Modification Intracellular Signal Transduction Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cullin Family Protein Binding SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cul7-RING Ubiquitin Ligase Complex NEDD8 Ligase Activity Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Protein-containing Complex Assembly NEDD8 Transferase Activity Modification-dependent Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Cytosol Protein Monoubiquitination Regulation Of Signal Transduction Regulation Of Protein Modification Process SCF Ubiquitin Ligase Complex Negative Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction FK506 Binding Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein-containing Complex Heterochromatin Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Proteolysis Epithelial To Mesenchymal Transition
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