DZIP1 and PPP2R5A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DZIP1	PPP2R5A
Description		DAZ interacting zinc finger protein 1	protein phosphatase 2 regulatory subunit B'alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Nuclear Speck Centriolar Satellite Ciliary Basal Body Cell Projection Ciliary Transition Fiber Ciliary Base	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Z Disc M Band
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity BBSome Binding	Protein Binding Kinase Inhibitor Activity Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity
	Biological Process	Smoothened Signaling Pathway Germ Cell Development Spermatogenesis Heart Development Cell Projection Organization Cell Differentiation Ciliary Basal Body Organization Protein Localization To Organelle Cilium Organization Establishment Of Protein Localization Positive Regulation Of Cilium Assembly Establishment Of Localization In Cell Cilium Assembly Protein Localization To Cilium Sperm Flagellum Assembly Protein-containing Complex Localization To Centriolar Satellite Positive Regulation Of Protein Localization To Cilium	Signal Transduction Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Hedgehog 'on' state	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation PKR-mediated signaling
Drugs
Diseases
GWAS		Glomerular filtration rate (cystatin C) ( 26831199) Response to statins (LDL cholesterol change) ( 25350695)	Deep white matter hyperintensities ( 32517579) HDL cholesterol levels ( 32203549) Nickel levels ( 26025379) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		14 interacting genes: APAF1 DAZ1 DAZ4 LUC7L2 MECOM MOS OPTN PPP1R18 PPP2R5A PRPF40A RNF10 TIAM1 TNS2 UGGT2	29 interacting genes: APC AXIN2 BCL2 BEST1 BUB1B CDCA2 CHEK2 CSNK1A1 CTLA4 DAPK1 DZIP1 EIF2AK2 ERICH4 GNL3 JAK2 MAPT MOS NEK1 NEK2 NOS3 PPFIA1 PPP2R1A PTTG1 SGO1 SHC1 SHFL TNNT2 TP63 USHBP1
Entrez ID		22873	5525
HPRD ID		16363	03384
Ensembl ID		ENSG00000134874	ENSG00000066027
Uniprot IDs		B3KSP1 Q86YF9	Q15172
PDB IDs			6NTS 8SZK
Enriched GO Terms of Interacting Partners?		Translation Activator Activity 3'-UTR-mediated MRNA Stabilization Kinase Binding U2-type Prespliceosome U1 SnRNP	Cell Division Organelle Organization Protein Serine Kinase Activity Protein Kinase Activity Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Protein Serine/threonine Kinase Activity Kinase Activity Beta-catenin Destruction Complex Negative Regulation Of Osteoblast Proliferation Protein Phosphorylation Regulation Of Organelle Organization Protein Autophosphorylation Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Phosphorylation Chromosome Segregation Regulation Of Nuclear Division Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Cytosol Kinetochore Chromosome, Centromeric Region Centrosome Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Osteoblast Proliferation Regulation Of Protein Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Cytoskeleton Organization Negative Regulation Of Cell Cycle Phase Transition Protein Phosphatase Regulator Activity Regulation Of Mitotic Nuclear Division Sister Chromatid Cohesion Regulation Of Cell Cycle Phase Transition Cytoskeleton Microtubule Cytoskeleton Organization Nuclear Chromosome Segregation Chromosome Signal Transduction Nucleus Axon Development Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Regulation Of Signaling
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