FGR and DOK1

Number of citations of the paper that reports this interaction (PubMedID 11071635)
0

Data Source:
HPRD (in vitro)

		FGR	DOK1
Description		FGR proto-oncogene, Src family tyrosine kinase	docking protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Aggresome Ruffle Membrane Secretory Granule Lumen Cell Projection Extracellular Exosome	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding	Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Response To Virus Peptidyl-tyrosine Phosphorylation Cell Differentiation Bone Mineralization Positive Regulation Of Cell Migration Negative Regulation Of Natural Killer Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Skeletal System Morphogenesis Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Intracellular Signal Transduction Macrophage Colony-stimulating Factor Signaling Pathway
Pathways		FCGR activation Platelet sensitization by LDL Neutrophil degranulation FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling
Drugs		Dasatinib Fostamatinib Zanubrutinib
Diseases
GWAS		Body mass index ( 28892062) Systolic blood pressure ( 30224653)	Bell's palsy ( 33602968) Height ( 31562340)
Interacting Genes		30 interacting genes: AR ARRB1 CBL CCR3 CSK DAB2 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG HCLS1 IKBKG INPP5D KHDRBS1 KIT MET NR1I2 PTK2 SKAP2 SLAMF1 SMURF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ	42 interacting genes: ABL1 ABL2 BCR CRK CRKL CSDE1 CSK DOK3 ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC TLN1 VAV1 YES1
Entrez ID		2268	1796
HPRD ID		01288	04228
Ensembl ID		ENSG00000000938	ENSG00000115325
Uniprot IDs		P09769 P78453	B3KP83 B4DJN1 Q14CB2 Q2TA81 Q99704
PDB IDs		7JT9 7UY0 7UY3	2V76
Enriched GO Terms of Interacting Partners?		Signal Transduction Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death SH2 Domain Binding Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process ERBB2 Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Regulation Of ERK1 And ERK2 Cascade Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Immune System Process Plasma Membrane Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Gene Expression Positive Regulation Of MAPK Cascade ERBB Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Kinase Activity Negative Regulation Of Apoptotic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Cell Adhesion Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Motility Positive Regulation Of Cell Adhesion Immune Response-regulating Signaling Pathway Protein Kinase Activity Regulation Of Immune Response Protein Phosphorylation Kinase Activity Immune Response-activating Signaling Pathway Plasma Membrane Leukocyte Migration Integrin-mediated Signaling Pathway Phosphorylation Immune System Process Activation Of Immune Response Fc-gamma Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction T Cell Costimulation Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Regulation Of Signal Transduction
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