ALDOA and IFNA4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ALDOA	IFNA4
Description		aldolase, fructose-bisphosphate A	interferon alpha 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Secretory Granule Lumen Sperm Head Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	RNA Binding Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Lyase Activity Identical Protein Binding Cadherin Binding Fructose Binding	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding
	Biological Process	Fructose Metabolic Process Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Binding Of Sperm To Zona Pellucida Regulation Of Cell Shape Fructose 1,6-bisphosphate Metabolic Process Muscle Cell Cellular Homeostasis Protein Homotetramerization	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Defense Response Humoral Immune Response Response To Virus Response To Exogenous DsRNA Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Virus
Pathways		Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses
Drugs		Zinc 1,6-Fructose Diphosphate (Linear Form) Dihydroxyacetone phosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		37 interacting genes: ADRB2 ATP6V1E1 BCAT2 CACNA1A CEBPA CYTH2 DSCR9 DYNLL1 ENO1 ENO3 ERBB2 ERBB3 ERBB4 FANCA GALNT6 GPD2 HSD17B10 HSPB2 IFNA4 LCOR LINC01554 MLH1 MYOC NXF1 OGT PCNA PIAS4 PLD2 SHANK3 SLC22A1 SRPK2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1	1 interacting genes: ALDOA
Entrez ID		226	3441
HPRD ID		00070	00952
Ensembl ID		ENSG00000149925	ENSG00000236637
Uniprot IDs		P04075 V9HWN7	P05014
PDB IDs		1ALD 2ALD 4ALD 5KY6 6XMH 6XML 6XMM 6XMO
Enriched GO Terms of Interacting Partners?		ERBB2 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB3:ERBB2 Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Basal Plasma Membrane Neuregulin Receptor Activity Negative Regulation Of DNA Metabolic Process ERBB Signaling Pathway Isoleucine Metabolic Process L-isoleucine Catabolic Process ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Adaptation Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation ERBB4 Signaling Pathway Telomere Localization Gluconeogenesis Hexose Biosynthetic Process Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Response To Stress Regulation Of Small GTPase Mediated Signal Transduction Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of DNA Metabolic Process Receptor Complex Regulation Of Purine Nucleotide Metabolic Process Canonical Glycolysis Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of DNA Biosynthetic Process Dopamine Transport Brown Fat Cell Differentiation Positive Regulation Of Excitatory Postsynaptic Potential Import Into Cell Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Protein-containing Complex Binding Positive Regulation Of Mini Excitatory Postsynaptic Potential Branched-chain Amino Acid Metabolic Process Branched-chain Amino Acid Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glycolytic Process Through Glucose-6-phosphate M Band Nicotinamide Nucleotide Metabolic Process	ADP Catabolic Process ATP Biosynthetic Process Muscle Cell Cellular Homeostasis Fructose Metabolic Process Pyruvate Metabolic Process M Band Striated Muscle Contraction Tubulin Binding Sperm Head Purine Ribonucleotide Catabolic Process ADP Metabolic Process Cytoskeletal Protein Binding Protein Homotetramerization Purine Ribonucleoside Diphosphate Catabolic Process Platelet Alpha Granule Lumen Nucleoside Diphosphate Catabolic Process Fructose-bisphosphate Aldolase Activity Tertiary Granule Lumen Ribonucleoside Diphosphate Metabolic Process Fructose Binding Glycolytic Process I Band Binding Of Sperm To Zona Pellucida Fructose 1,6-bisphosphate Metabolic Process Purine Nucleotide Catabolic Process Sperm-egg Recognition Cell-cell Recognition Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Protein Tetramerization Nucleoside Triphosphate Biosynthetic Process Nucleotide Catabolic Process Cell Recognition Nicotinamide Nucleotide Metabolic Process Ficolin-1-rich Granule Lumen Carbohydrate Catabolic Process Secretory Granule Lumen Nucleoside Phosphate Catabolic Process Purine Ribonucleotide Biosynthetic Process Regulation Of Cell Shape Lyase Activity ATP Metabolic Process Ribose Phosphate Biosynthetic Process Hexose Metabolic Process Purine Nucleotide Biosynthetic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Organophosphate Catabolic Process Protein Homooligomerization Muscle Contraction
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