FGF10 and POMC

Number of citations of the paper that reports this interaction (PubMedID 12591959)
52

Data Source:
HPRD (in vitro)

		FGF10	POMC
Description		fibroblast growth factor 10	proopiomelanocortin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen
	Molecular Function	Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Angiogenesis Metanephros Development Organ Induction Mesonephros Development Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Blood Vessel Remodeling Metanephros Morphogenesis Chemotaxis Cell-cell Signaling Determination Of Left/right Symmetry Salivary Gland Development Salivary Gland Morphogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Regulation Of Smoothened Signaling Pathway Embryonic Pattern Specification Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Keratinocyte Proliferation Wnt Signaling Pathway Pituitary Gland Development Neurogenesis Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Lung Development Regulation Of Cell Migration Embryonic Genitalia Morphogenesis Epithelial Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Thyroid Gland Development Otic Vesicle Formation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Pancreas Development Hair Follicle Morphogenesis Embryonic Camera-type Eye Development Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of ATP-dependent Activity Lacrimal Gland Development Regulation Of Activin Receptor Signaling Pathway Protein Localization To Cell Surface Somatic Stem Cell Population Maintenance Limb Morphogenesis Organ Growth Wound Healing Tissue Regeneration Inner Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Muscle Cell Fate Commitment Positive Regulation Of MAPK Cascade Keratinocyte Proliferation Positive Regulation Of DNA Repair Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ras Protein Signal Transduction Regulation Of Saliva Secretion Vascular Endothelial Growth Factor Receptor Signaling Pathway Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Blood Vessel Morphogenesis Spleen Development Thymus Development Embryonic Digestive Tract Morphogenesis Digestive Tract Development Embryonic Digestive Tract Development Animal Organ Formation Epidermis Morphogenesis Semicircular Canal Morphogenesis Branching Morphogenesis Of An Epithelial Tube Female Genitalia Morphogenesis Male Genitalia Morphogenesis Positive Regulation Of Lymphocyte Proliferation Epithelial Cell Proliferation Urothelial Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation White Fat Cell Differentiation Positive Chemotaxis Induction Of Positive Chemotaxis Smooth Muscle Cell Differentiation Positive Regulation Of Keratinocyte Migration Radial Glial Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Limb Development Limb Bud Formation Lung Morphogenesis Lung Epithelium Development Lung Saccule Development Bronchiole Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Outgrowth Involved In Lung Branching Bud Elongation Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Lung Development Type II Pneumocyte Differentiation Prostatic Bud Formation Respiratory System Development Mammary Gland Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Mammary Gland Bud Formation Submandibular Salivary Gland Formation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Branch Elongation Involved In Salivary Gland Morphogenesis Semicircular Canal Fusion Mesenchymal Cell Differentiation Involved In Lung Development Secretion By Lung Epithelial Cell Involved In Lung Growth Lung Proximal/distal Axis Specification Tear Secretion White Fat Cell Proliferation Positive Regulation Of White Fat Cell Proliferation ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Harderian Gland Development Positive Regulation Of Hair Follicle Cell Proliferation Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Negative Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Killing Of Cells Of Another Organism Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Modulation Of Process Of Another Organism Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Glycogen Metabolic Process Positive Regulation Of Neutrophil Mediated Killing Of Fungus Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Oxytocin Production Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion
Pathways		PI3K Cascade PIP3 activates AKT signaling FGFR1b ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Regulation of gene expression in early pancreatic precursor cells Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Developmental Lineage of Multipotent Pancreatic Progenitor Cells Developmental Lineage of Mammary Stem Cells	Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Loperamide Etorphine Dihydromorphine
Diseases		Aplasia of lacrimal and salivary glands Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
GWAS		Alzheimer disease and age of onset ( 26830138) Basal cell carcinoma ( 31174203) Breast cancer ( 29059683 31757997) Dentures ( 31235808) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) High altitude adaptation ( 28373541) Keratinocyte cancer (MTAG) ( 31174203) Lung function (FVC) ( 30175238 30804560) Nonsyndromic cleft lip with cleft palate ( 28232668) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Parkinson's disease ( 26227905) Prostate cancer ( 21743467) Refractive error ( 32231278)	Body mass index ( 20935630 23669352 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 18391951 23563607 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)
Interacting Genes		6 interacting genes: FBXO7 FGFR1 FGFR2 POMC SREK1IP1 THAP1	28 interacting genes: ABI2 AIRIM APP ATP6V0D2 BHLHA9 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN
Entrez ID		2255	5443
HPRD ID		03665	01462
Ensembl ID		ENSG00000070193	ENSG00000115138
Uniprot IDs		O15520	P01189
PDB IDs		1NUN	4XNH 4XPD 4Y49 6TUB 7F53 7F54 7PIV 8F7Q 8INR 8IOC
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Positive Regulation Of Phospholipase Activity Fibroblast Growth Factor Receptor Activity Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Lipase Activity Lung-associated Mesenchyme Development Branching Involved In Salivary Gland Morphogenesis Fibroblast Growth Factor Binding Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Midbrain Development Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Organ Growth Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Morphogenesis Of A Branching Structure Mesenchyme Development Inner Ear Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of Heart Growth Kidney Epithelium Development Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Positive Regulation Of Oxytocin Production Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Epithelial To Mesenchymal Transition Biomineral Tissue Development Regulation Of Organ Growth Regulation Of Mitotic Cell Cycle Lung Development Stem Cell Differentiation	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Feeding Behavior Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Hormone Binding G Protein-coupled Receptor Activity Regulation Of Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Chemoattractant Activity Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Binding Protein Serine/threonine Kinase Binding Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Bronchiole Morphogenesis Urothelial Cell Proliferation Embryonic Genitalia Morphogenesis Semicircular Canal Fusion Mesenchymal-epithelial Cell Signaling Involved In Lung Development Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Submandibular Salivary Gland Formation Corticotropin Receptor Activity Neuropeptide Binding Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Sulfite Oxidase Activity Symbiont-containing Vacuole Protein-N-terminal Glutamine Amidohydrolase Activity Glycerate Kinase Activity
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