BEND7 and TLK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BEND7	TLK1
Description		BEN domain containing 7	tousled like kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process		Chromatin Organization Protein Phosphorylation Intracellular Protein Transport DNA Damage Response Chromosome Segregation Intracellular Signal Transduction Regulation Of Chromatin Organization
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Diastolic blood pressure ( 30224653) Free thyroxine concentration ( 30367059) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900) Schizophrenia x sex interaction ( 34099189) Skin pigmentation ( 28300201) Smoking status (ever vs never smokers) ( 30643258) White blood cell count ( 32888494)	Autism spectrum disorder ( 34069769) Health literacy ( 31250787) Liver enzyme levels (alkaline phosphatase) ( 33972514) Menopause (age at onset) ( 22267201 26414677) Platelet distribution width ( 27863252 32888494)
Interacting Genes		75 interacting genes: ANP32B BANF2 BYSL C14orf119 CDC37 CDCA7L CEP44 CHD2 CIB3 CSNK2A1 DDX6 DVL2 DVL3 EAF1 EAF2 EIF1AD EMD FAM124A FAM133A GADD45G GEMIN2 GTPBP3 GYS1 HMBOX1 HSF2BP KANK2 L3MBTL2 LMO3 LNX1 LYAR MAGOHB MBD2 MFAP1 MLX MORF4L1 MORF4L2 MYO15B NAP1L3 NEK6 NIF3L1 NKAPD1 NOL12 NUTF2 OGT OSGIN1 PBLD PIM1 PLEKHF2 POLR3GL PPIG PPP1R37 PRMT3 PRPF40A PSMB1 PSMF1 RAB29 RBM10 RIPPLY1 RPL22 SCNM1 SDCBP SDCBP2 SMARCA2 SPANXN2 THAP1 TLK1 TNPO2 TRIM26 U2AF2 UBL5 USP20 VCX2 WHRN ZCCHC10 ZNF622	28 interacting genes: ASF1A ASF1B AURKA BEND7 CHEK1 CXCR5 DPPA4 GPRASP3 H1-1 LHX2 LUZP4 MBP NBN PAX6 PINX1 PTPN11 RAD9A SNAP23 TFCP2 TLK2 TPM3 UBE3C YAF2 YWHAE ZNF655 ZNF773 ZNF829 ZSCAN22
Entrez ID		222389	9874
HPRD ID		12570	12232
Ensembl ID		ENSG00000165626	ENSG00000198586
Uniprot IDs		A0AAK2PQJ4 Q8N7W2	B3KRP1 Q9UKI8
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Protein Binding RNA Splicing, Via Transesterification Reactions Nuclear Speck MRNA Splicing, Via Spliceosome RNA Splicing RNA Metabolic Process Positive Regulation Of JNK Cascade Sin3-type Complex RNA Processing Nucleic Acid Metabolic Process Non-canonical Inflammasome Complex Assembly Super Elongation Complex Identical Protein Binding Positive Regulation Of Neuron Projection Arborization Frizzled Binding Regulation Of JNK Cascade Transcription Elongation Factor Activity MRNA Processing	Regulation Of Mitotic Cell Cycle Nucleus Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Chromatin Organization Chromatin Remodeling Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Telencephalon Regionalization Regulation Of Cell Cycle G2/M Phase Transition DNA Replication-dependent Chromatin Assembly Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Histone Chaperone Activity Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Cerebral Cortex Development Nucleoplasm Protein Localization To Organelle Protein Localization To Chromosome Nucleosome Assembly RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Replication Fork Protein Binding Regulation Of DNA Recombination Mitotic G2 DNA Damage Checkpoint Signaling DNA Damage Response Positive Regulation Of Mitotic Cell Cycle Protein-containing Complex Chromatin Negative Regulation Of DNA Metabolic Process DNA Binding Nucleosome Organization Positive Regulation Of Metalloendopeptidase Activity Astrocyte Differentiation Forebrain-midbrain Boundary Formation Pancreatic A Cell Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Protein Export From Nucleus Negative Regulation Of Telomere Maintenance
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