FDFT1 and ELP4

		FDFT1	ELP4
Description		farnesyl-diphosphate farnesyltransferase 1	elongator acetyltransferase complex subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	Catalytic Activity Protein Binding Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Metal Ion Binding Squalene Synthase [NAD(P)H] Activity	Protein Binding Phosphorylase Kinase Regulator Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process Farnesyl Diphosphate Metabolic Process	TRNA Wobble Uridine Modification Regulation Of Transcription By RNA Polymerase II Regulation Of Translation TRNA Processing
Pathways		Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)	HATs acetylate histones
Drugs		TAK-475
Diseases
GWAS		A body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Platelet count ( 32888494) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Glaucoma ( 25027321) Mental health study participation (completed survey) ( 31263887) Optic disc area ( 25631615) Optic disc size ( 31809533) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		26 interacting genes: ANXA5 AQP6 ARL13B ARL6IP1 CD74 CD79A CLN5 CREB3 ELOVL4 ELP4 FAM209A GJA8 GPR152 ITGB5 JAGN1 LMNA NCAPH2 PANX1 RFLNA RUVBL2 SHPRH SLC10A1 SLC35H1 TLCD4 TMEM43 TMX2	8 interacting genes: ELP3 ELP5 ELP6 FDFT1 HINFP NAGK PAMR1 PPP1CC
Entrez ID		2222	26610
HPRD ID		01694	07377
Ensembl ID		ENSG00000079459	ENSG00000109911
Uniprot IDs		A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1	G5E9D4 Q96EB1
PDB IDs		1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA 6PYJ 6PYV 6PYW 6PZ5 8WTQ 8WTR
Enriched GO Terms of Interacting Partners?		Membrane Monoatomic Anion Channel Activity Endoplasmic Reticulum Endoplasmic Reticulum Membrane Identical Protein Binding	Elongator Holoenzyme Complex TRNA Wobble Uridine Modification TRNA Modification TRNA Processing RNA Modification TRNA Metabolic Process Squalene Synthase [NAD(P)H] Activity Inflammasome-mediated Signaling Pathway TRNA Uridine(34) Acetyltransferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity TRNA Binding Regulation Of Translation Cytoplasmic Pattern Recognition Receptor Signaling Pathway N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Homeostasis Of Number Of Retina Cells TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Phosphorylase Kinase Regulator Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility N-acetylglucosamine Catabolic Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Locomotion Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Farnesyl Diphosphate Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Ubiquitin Recycling Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Catabolic Process PTW/PP1 Phosphatase Complex Innate Immune Response-activating Signaling Pathway Protein Linear Polyubiquitination Activation Of Innate Immune Response Intracellular Receptor Signaling Pathway UDP-N-acetylglucosamine Biosynthetic Process MAPK Cascade RNA Processing Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Metabolic Process Intracellular Signal Transduction
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