MTURN and RNF41

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTURN	RNF41
Description		maturin, neural progenitor differentiation regulator homolog	ring finger protein 41
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Signaling Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of ERK1 And ERK2 Cascade	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cadmium levels ( 26025379)	Asthma ( 31619474) Height ( 34054925)
Interacting Genes		23 interacting genes: AP2M1 APP ARRDC1 DAZAP2 MKRN1 PLEKHB2 REL RNF41 RPS27A SH3RF1 SSX1 SUSD6 TMEM239 TNFRSF19 TP53BP2 TRAF6 TRIM38 TRIM39 TRIM5 TRIM8 UBA52 UBB UBC	45 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 GDF11 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 NEUROD4 ORMDL2 PPP1R1A RAD23A RFC4 RNF166 RRM2B SRR SUOX TBATA TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70
Entrez ID		222166	10193
HPRD ID		07635	11520
Ensembl ID		ENSG00000180354	ENSG00000181852
Uniprot IDs		Q8N3F0	F8VSB6 Q9H4P4
PDB IDs			2FZP 2GWF
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Tag Activity Ubiquitin Protein Ligase Activity Protein Modification Process Endocytic Vesicle Membrane Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Innate Immune Response Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Proteolysis Involved In Protein Catabolic Process Endosome Membrane Defense Response To Symbiont Regulation Of JNK Cascade Positive Regulation Of Cell Communication Defense Response To Other Organism Positive Regulation Of Signaling Canonical NF-kappaB Signal Transduction Modification-dependent Protein Catabolic Process Vesicle Protein Autoubiquitination Regulation Of Protein Catabolic Process Protein K63-linked Ubiquitination Mitochondrial Outer Membrane Regulation Of Signal Transduction Regulation Of MAPK Cascade Cytosol Suppression Of Viral Release By Host Identical Protein Binding Positive Regulation Of MAPK Cascade Macromolecule Catabolic Process Regulation Of Viral Entry Into Host Cell Protein Serine/threonine Kinase Binding Host-mediated Suppression Of Symbiont Invasion Response To Other Organism Zinc Ion Binding Transcription Coactivator Activity Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Receptor Internalization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Lipopolysaccharide-mediated Signaling Pathway Proteolysis	Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination
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