OARD1 and RSPH9

		OARD1	RSPH9
Description		O-acyl-ADP-ribose deacylase 1	radial spoke head component 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Site Of DNA Damage	Radial Spoke Radial Spoke Head Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Kinocilium 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3
	Molecular Function	Purine Nucleoside Binding Protein Binding Hydrolase Activity ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity	Protein Binding
	Biological Process	DNA Damage Response Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation	Cilium Movement Cell Projection Organization Axoneme Assembly Motile Cilium Assembly Cilium Movement Involved In Cell Motility Radial Spoke Assembly Axonemal Central Apparatus Assembly
Pathways
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Adult body size ( 32376654) Alzheimer's disease (late onset) ( 30820047) Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)	Intracranial aneurysm ( 29531279) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: APP PICK1 RAPGEF3 RSPH9 TNKS	11 interacting genes: ADCY10P1 DRC5 HMG20A KLHDC3 LINC03040 LRRC73 OARD1 PNMA1 SPATS1 TAF8 TSPO2
Entrez ID		221443	221421
HPRD ID		12849	12875
Ensembl ID		ENSG00000124596	ENSG00000172426
Uniprot IDs		C9J5P1 C9JA90 C9JXC3 Q05CR9 Q9Y530	Q9H1X1
PDB IDs		2EEE 2L8R 2LGR 4J5Q 4J5R 4J5S	8J07
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Component Organization Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Amylin Binding Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To CAMP Regulation Of Protein Transport Regulation Of Receptor Internalization Positive Regulation Of Receptor Internalization Glial Cell Development Response To CAMP Associative Learning Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Purine-containing Compound Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Receptor-mediated Endocytosis Learning Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cellular Component Organization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Radial Spoke Head 1 Radial Spoke Assembly Radial Spoke Head 3 Plasma Membrane Bounded Cell Projection Organization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Synaptic Plasticity Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Norepinephrine Stimulus	DNA-templated Transcription Open Complex Formation ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity
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