FCER1G and MIF

		FCER1G	MIF
Description		Fc epsilon receptor Ig	macrophage migration inhibitory factor
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Fc-epsilon Receptor I Complex Fc-gamma Receptor III Complex Tertiary Granule Membrane Plasma Membrane Protein Complex Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding Protein Homodimerization Activity	Protease Binding Dopachrome Isomerase Activity Cytokine Activity Cytokine Receptor Binding Protein Binding Isomerase Activity Chemoattractant Activity Identical Protein Binding Phenylpyruvate Tautomerase Activity
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Signal Transduction Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Immune Response Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface	Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine Production Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Carboxylic Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Chemotaxis Negative Regulation Of Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cellular Response To Stress Positive Regulation Of Arachidonate Secretion Cellular Senescence Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Cellular Senescence
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen	Cell surface interactions at the vascular wall Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Benzylpenicilloyl polylysine	3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester 4-Hydroxyphenylpyruvic acid 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS		Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 30929738 31361310 31619474 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) White blood cell count ( 32888494)	Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macrophage Migration Inhibitory Factor levels ( 27989323) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		93 interacting genes: ADGRE2 C2CD2L CDIPT CERS4 CLCA4 CLEC4E CNIH1 COX20 COX8A CYP4F2 DEFB127 DGAT2L6 EBP F5 FA2H FAM209A FAXDC2 FCER1A FCGR2A FCGR2B FCGR3A FFAR2 FUNDC2 FXYD6 GIMAP5 GJA5 GP6 GPR61 IER3IP1 KCNA1 KCNN3 KIR2DL4 LEPROTL1 LMNA LNPEP LYN MFF MGLL MIF NCR1 NCR3 NHERF4 NIT1 NRM ORMDL2 PDZK1IP1 PEMT PEX16 PLCG2 PLP2 PTPN5 RUSF1 SEC22B SELP SFXN1 SFXN3 SLC10A1 SLC13A4 SLC18A1 SLC1A1 SLC30A8 SLC35G2 SLC38A7 SLC39A2 SLC39A9 SLC7A1 SLC7A14 SMIM1 SPRR1A STX12 SYK SYNJ2BP SYS1 THBD TMEM107 TMEM120B TMEM140 TMEM14B TMEM179B TMEM19 TMEM218 TMEM31 TPRG1 TSPO TSPO2 UBE2J1 UBIAD1 UNC50 UNC93A VAMP1 YIF1A YIPF4 YIPF6	17 interacting genes: BEX3 BNIPL CD74 CEBPA COPS5 COPS6 EGFR EXOSC7 FCER1G GNAL GORASP2 NME1 NTAQ1 STRN4 TP53 UPF2 ZNF408
Entrez ID		2207	4282
HPRD ID		00916	01091
Ensembl ID		ENSG00000158869	ENSG00000240972
Uniprot IDs		P30273	I4AY87 P14174
PDB IDs		7Q5T 8YVU 8YWA	1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ 4PLU 4TRF 4TRU 4WR8 4WRB 4XX7 4XX8 4Z15 4Z1T 4Z1U 5B4O 5BS9 5BSC 5BSI 5BSJ 5EIZ 5HVS 5HVT 5HVV 5J7P 5J7Q 5UMJ 5UMK 5UZY 5V70 5V73 5XEJ 6B1C 6B1K 6B2C 6BG6 6BG7 6CB5 6CBF 6CBG 6CBH 6FVE 6FVH 6OY8 6OYB 6OYE 6OYG 6PEG 7E45 7E47 7E49 7E4A 7E4B 7E4C 7KQX 7XTX 7XVX 8CA0 8IMR 8SON 8SPN 8TT9 9BNQ 9BNR
Enriched GO Terms of Interacting Partners?		Membrane Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Endoplasmic Reticulum Membrane Protein Binding Monoatomic Ion Transport Transmembrane Transport Hypersensitivity Immune Response-regulating Signaling Pathway Regulation Of Platelet Activation Amino Acid Transmembrane Transport Plasma Membrane Mitochondrial Membrane Acute Inflammatory Response To Antigenic Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway IgG Receptor Activity Amino Acid Transport Endoplasmic Reticulum Regulation Of Tumor Necrosis Factor Production Organic Cation Transport Fc-epsilon Receptor Signaling Pathway Antibody-dependent Cellular Cytotoxicity Monoatomic Cation Transport Zinc Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Zinc Ion Transport Metal Ion Transport Lipid Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Low-affinity IgG Receptor Activity Immune Receptor Activity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Monoatomic Ion Transmembrane Transporter Activity Inflammatory Response To Antigenic Stimulus IgG Binding COPII-coated ER To Golgi Transport Vesicle Monoatomic Ion Transmembrane Transport Immunoglobulin Mediated Immune Response Regulation Of Cytokine Production Involved In Immune Response Serine Import Into Mitochondrion B Cell Mediated Immunity Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Organic Anion Transport Neutral Amino Acid Transport Regulation Of Secretion Nuclear Inner Membrane Inflammatory Response Follicular B Cell Differentiation	Macrophage Migration Inhibitory Factor Binding Identical Protein Binding T Cell Activation Involved In Immune Response Protein Deneddylation Metal-dependent Deubiquitinase Activity Regulation Of Fibroblast Proliferation Regulation Of Protein Neddylation Protein Neddylation Regulation Of Fatty Acid Biosynthetic Process Cytokine-mediated Signaling Pathway MHC Class II Protein Binding, Via Antigen Binding Groove Lymphocyte Activation Involved In Immune Response NOS2-CD74 Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Macrophage Migration Inhibitory Factor Signaling Pathway Cell Activation Involved In Immune Response Regulation Of Protein Modification Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Metabolic Process Antigen Processing And Presentation Of Exogenous Antigen Leukocyte Activation Involved In Immune Response B Cell Mediated Immunity Protein-containing Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immunoglobulin Mediated Immune Response Negative Regulation Of Stem Cell Proliferation Embryonic Organ Development Embryonic Placenta Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Multivesicular Body, Internal Vesicle Lumen Leukocyte Apoptotic Process IgE Receptor Activity Farnesyl Diphosphate Kinase Activity Succinyl-CoA Binding Protein Phosphatase 2A Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition COP9 Signalosome Protein-N-terminal Glutamine Amidohydrolase Activity Nucleus Negative Regulation Of Apoptotic Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Apoptotic Process Protein Complex Oligomerization Regulation Of Apoptotic Process
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