ALDH3A1 and ZFTRAF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ALDH3A1	ZFTRAF1
Description		aldehyde dehydrogenase 3 family member A1	zinc finger TRAF-type containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane	Nucleus Nuclear Envelope Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase (NAD+) Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Aldehyde Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process
Pathways		Phase I - Functionalization of compounds
Drugs		NADH
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Refractive astigmatism ( 30306274)
Interacting Genes		5 interacting genes: FBXL12 FKBP6 POT1 SRF ZFTRAF1	13 interacting genes: ALDH3A1 FXR1 HOXA1 KPNA3 KPNA4 KRTAP1-1 KRTAP1-3 LGALS3 MAPK9 NBPF19 NOTCH2NLA PVR SDCBP
Entrez ID		218	50626
HPRD ID		00004	13107
Ensembl ID		ENSG00000108602	ENSG00000187954
Uniprot IDs		I3L3I9 P30838 Q6PKA6	P0DTL6
PDB IDs		3SZA 3SZB 4H80 4L1O 4L2O 8BB8
Enriched GO Terms of Interacting Partners?		Serum Response Element Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Trachea Cartilage Development Bronchus Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Lung Smooth Muscle Development Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Positive Regulation Of Transcription By Glucose Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Dorsal Aorta Morphogenesis Primary MiRNA Binding Tangential Migration From The Subventricular Zone To The Olfactory Bulb Single-stranded Telomeric DNA Binding Telomerase Inhibitor Activity Nuclear Telomere Cap Complex Shelterin Complex Telomeric D-loop Disassembly DEAD/H-box RNA Helicase Binding Establishment Of Protein Localization To Telomere Negative Regulation Of Amyloid-beta Clearance Primitive Streak Formation Cardiac Muscle Cell Myoblast Differentiation FK506 Binding Telomeric Loop Disassembly G-rich Strand Telomeric DNA Binding Skin Morphogenesis Positive Thymic T Cell Selection Cardioblast Differentiation Transposable Element Silencing By PiRNA-mediated DNA Methylation Telomere Capping Heart Trabecula Formation Eyelid Development In Camera-type Eye Positive T Cell Selection Cardiac Myofibril Assembly Long-term Synaptic Depression Regulation Of DNA Strand Elongation Face Development Angiogenesis Involved In Wound Healing Trophectodermal Cell Differentiation Regulation Of Amyloid-beta Clearance Platelet Formation Contractile Actin Filament Bundle Assembly	NLS-dependent Protein Nuclear Import Complex NLS-bearing Protein Import Into Nucleus Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding
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