ALDH2 and SIRT3

Number of citations of the paper that reports this interaction (PubMedID 28248093)
29

Data Source:
BioGRID (enzymatic study)

		ALDH2	SIRT3
Description		aldehyde dehydrogenase 2 family member	sirtuin 3
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Exosome	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Protein-containing Complex
	Molecular Function	Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Phenylacetaldehyde Dehydrogenase (NAD+) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor NAD Binding Carboxylesterase Activity	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Transferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Histone Deacetylase Activity, NAD-dependent Enzyme Binding Protein Lysine Deacetylase Activity NAD-dependent Protein Lysine Deacetylase Activity Sequence-specific DNA Binding Metal Ion Binding NAD+ Binding NAD-dependent Protein Lysine Delactylase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Carbohydrate Metabolic Process Alcohol Metabolic Process Ethanol Metabolic Process Ethanol Catabolic Process Nitroglycerin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Regulation Of Dopamine Biosynthetic Process Regulation Of Serotonin Biosynthetic Process	Protein Deacetylation Aerobic Respiration Positive Regulation Of Insulin Secretion Cellular Response To Stress Peptidyl-lysine Deacetylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Catalase Activity Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Metabolism of serotonin Smooth Muscle Contraction Ethanol oxidation Mitochondrial protein degradation	Transcriptional activation of mitochondrial biogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Mitochondrial unfolded protein response (UPRmt) Maturation of TCA enzymes and regulation of TCA cycle
Drugs		NADH Guanidine Disulfiram Daidzin Crotonaldehyde	Adenosine-5-Diphosphoribose
Diseases		Acute alcohol sensitivity
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 31959922 28485404) Alcohol consumption (drinks per week) ( 31959922) Alcohol consumption (max-drinks) ( 29460428 24277619) Alcohol dependence ( 24277619) Alcohol dependence symptom count ( 29460428) Alcohol drinking status (current drinker vs non-current drinker) ( 34073884) Aspartate aminotransferase levels ( 30718733) Blood pressure ( 21572416) Body mass index ( 26426971 24861553 28892062) Coffee consumption ( 31959922 29367735) Confectionary intake ( 33632354) Coronary artery disease ( 30402224 33020668) Coronary heart disease ( 23364394 21971053) Crohn's disease ( 28067908 26192919) Diastolic blood pressure ( 25249183 26390057) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 21372407 23364009) Epilepsy ( 33913524) Esophageal cancer ( 19698717) Estimated glomerular filtration rate ( 31015462) Excessive alcohol consumption ( 33093602) Fish consumption ( 32895509) Fish intake frequency ( 31959922) Gamma glutamyl transferase levels ( 33093602) Gout ( 32238385) Gout (combined type) ( 32238385) Gout vs. Hyperuricemia ( 31289104) Green tea consumption ( 31959922) Height ( 31562340) Hematological and biochemical traits ( 20139978) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) Hypertension ( 32709000 25249183) Inflammatory bowel disease ( 26192919 28067908) Intracranial aneurysm ( 22286173) Ischemic stroke ( 26708676) Ischemic stroke (small artery occlusion) ( 26708676) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin concentration ( 20139978) Metabolic syndrome ( 28371326) Milk consumption ( 31959922) Myocardial infarction ( 30226566 24916648) Natto consumption ( 31959922) Oral cavity and pharyngeal cancer ( 21437268) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761) Renal function-related traits (sCR) ( 22797727) Renal overload gout ( 32238385) Renal underexcretion gout ( 32238385) Response to alcohol consumption (flushing response) ( 24277619 29460428) Serum alpha1-antitrypsin levels ( 26174136) Serum uric acid levels ( 29408531 29124443) Small vessel stroke (CCSp classification) ( 32047268) Smoking behaviour (cigarettes smoked per day) ( 31089300) Stroke (ischemic) ( 23041239) Sweet taste preference ( 32572145) Systolic blood pressure ( 26390057 25249183) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Tofu consumption ( 31959922) Triglycerides ( 26582766 22171074) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 34054925) Yoghurt consumption ( 31959922)	Coronary artery disease ( 33020668) Glycated hemoglobin levels ( 34059833) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Platelet count ( 24026423) Uterine fibroids ( 21460842 30194396)
Interacting Genes		15 interacting genes: ALDH1A1 APP CRMP1 DENND10P1 EIF6 ERG28 HSPB2 HSPD1 HSPE1 IGSF21 OGT RPL13A SIRT3 SLC35F6 UNC119	11 interacting genes: ALDH2 DNM1L ECHS1 GLDC H3C1 MCL1 MDM2 PDP1 PEX5 PYCR1 XRCC6
Entrez ID		217	23410
HPRD ID		00003	06836
Ensembl ID		ENSG00000111275	ENSG00000142082
Uniprot IDs		A0A384NPN7 P05091	E9PK80 E9PM75 E9PN58 Q9NTG7
PDB IDs		1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 4KWF 4KWG 5L13 8DR9 8SHS	3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4C78 4C7B 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9 4O8Z 5BWN 5BWO 5D7N 5H4D 5Y4H 5YTK 5Z93 5Z94 5ZGC 6ISO 8ANC 8BBK 8CCW 8CCZ 8HLW 8HLY 8HN9 8V15 8V2N 8V5U 9CBT
Enriched GO Terms of Interacting Partners?		Synapse Regulation Of Glycolytic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Response To Unfolded Protein Protein-folding Chaperone Binding Apolipoprotein Binding Unfolded Protein Binding Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cellular Component Organization Protein Refolding Aminobutyraldehyde Dehydrogenase (NAD+) Activity 3-deoxyglucosone Dehydrogenase Activity Fructosamine Catabolic Process Acetaldehyde Dehydrogenase (NAD+) Activity Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Translation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Folding Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Negative Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Lipid Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translational Initiation Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Negative Regulation Of Formation Of Translation Preinitiation Complex Regulation Of Phosphorus Metabolic Process Fructosamine Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Cell Junction Assembly Post-transcriptional Regulation Of Gene Expression Clathrin-coated Pit Lipoprotein Particle Mitochondrion Positive Regulation Of Protein Import Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Negative Regulation Of Cytoplasmic Translational Initiation Positive Regulation Of Type II Interferon Production	Mitochondrion Mitochondrial Matrix Cellular Response To Chemical Stress Protein-containing Complex Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Lyase Activity Cellular Response To Gamma Radiation Electron Transfer Activity Nitroglycerin Metabolic Process Phenylacetaldehyde Dehydrogenase (NAD+) Activity Regulation Of Serotonin Biosynthetic Process 3-hydroxypropionyl-CoA Dehydratase Activity Fatty Acid Beta-oxidation Carboxylic Acid Catabolic Process Amino Acid Metabolic Process Response To Gamma Radiation Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Response To Methylamine Negative Regulation Of Apoptotic Signaling Pathway Mitochondrion Organization Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Formaldehyde Cellular Response To Oxidative Stress Cellular Response To Vitamin B1 Endoplasmic Reticulum Organization Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Carboxylic Acid Metabolic Process Apoptotic Mitochondrial Changes Organic Acid Metabolic Process Cellular Response To Ionizing Radiation Small Molecule Metabolic Process Fatty Acid Catabolic Process Crotonyl-CoA Hydratase Activity Fatty Acid Oxidation Response To Lipoic Acid Protein Transmembrane Transport Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Mitochondrial Membrane Fission Regulation Of Peroxisome Organization Lipid Oxidation Response To Oxidative Stress DNA End Binding Cellular Response To Stress Ku70:Ku80 Complex Glycine Decarboxylation Via Glycine Cleavage System Glycine Cleavage Complex Glycine Catabolic Process
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