EZH2 and SMYD3

Number of citations of the paper that reports this interaction (PubMedID 22659877)
0

Data Source:
BioGRID (unspecified method)

		EZH2	SMYD3
Description		enhancer of zeste 2 polycomb repressive complex 2 subunit	SET and MYND domain containing 3
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Chromosome Pericentric Heterochromatin ESC/E(Z) Complex Pronucleus Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding DNA Binding Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Chromatin DNA Binding Nucleosome Binding Histone Methyltransferase Activity Histone Binding Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Histone H3K27 Methyltransferase Activity Primary MiRNA Binding LncRNA Binding Histone H3 Methyltransferase Activity Histone H3K27 Trimethyltransferase Activity Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Epidermal Cell Differentiation Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cardiac Muscle Hypertrophy In Response To Stress Cerebellar Cortex Development Hippocampus Development Hemopoiesis B Cell Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Regulatory NcRNA-mediated Heterochromatin Formation Heterochromatin Formation Subtelomeric Heterochromatin Formation Methylation Response To Estradiol Negative Regulation Of Transcription Elongation By RNA Polymerase II Cellular Response To Trichostatin A Protein Modification Process Hepatocyte Homeostasis Regulation Of Cell Population Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Stem Cell Differentiation Regulation Of Neurogenesis Negative Regulation Of Striated Muscle Cell Differentiation Synaptic Transmission, GABAergic Cellular Response To Hydrogen Peroxide G1 To G0 Transition Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kidney Development Liver Regeneration Facultative Heterochromatin Formation Positive Regulation Of Dendrite Development Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Tetrachloromethane Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Stem Cell Differentiation	Chromatin Organization Nucleosome Assembly Myotube Cell Development Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription	PKMTs methylate histone lysines
Drugs		Tazemetostat CPI-1205
Diseases
GWAS		Chronotype ( 30696823) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Familial squamous cell lung carcinoma ( 29924316) Height ( 25282103 31562340) Inflammatory bowel disease ( 28067908) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) DHEAS levels ( 34748635) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Malaria ( 31844061) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Renal underexcretion gout ( 32238385) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)
Interacting Genes		87 interacting genes: AKT1 AR ARID1A ATP1A1 ATP1B1 ATRX BCL11A BRCA1 C7orf25 CCDC85B CDK6 CDKN2B-AS1 CEP63 CRY2 DANCR DELEC1 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EP300 EPC2 FBXW7 GADD45G GTF3C1 H1-1 H2AC4 H3-4 H3C1 HAT1 HDAC1 HOTAIR HOXA11-AS JAK2 KAT2B KLHDC2 KRTAP10-9 LATS2 LINC00511 MAP3K20 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 MELK MUC1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRDM14 PRMT5 PSMB6 RASA1 RBL2 RCN3 RELA RELB RIN3 RPN2 RPS6KA5 SIRT1 SKIC8 SMARCA4 SMARCB1 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 TRIM55 TRIM63 TSPYL2 UCA1 USP1 VAV1 WSB2 ZMYND11	26 interacting genes: APP CAMK2B CFTR CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 LCOR MAP3K2 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K RNF113A SCCPDH SHC3 TRIT1 VANGL1 ZNF557
Entrez ID		2146	64754
HPRD ID		03342	12297
Ensembl ID		ENSG00000106462	ENSG00000185420
Uniprot IDs		A0A090N8E9 F2YMM1 Q15910 S4S3R8	B3KN46 Q9H7B4
PDB IDs		4MI0 4MI5 5GSA 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5LS6 5U5T 5U62 5WG6 5WUK 6C23 6C24 6LO2 6P5L 6U4Y 6WKR 7AT8 7QJG 7QJU 7QK4 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH	3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF 6YUH 6ZRB 7BJ1 7O2A 7O2B 7O2C 7QLB 7QNR 7QNU 8OWO
Enriched GO Terms of Interacting Partners?		Chromatin Organization Epigenetic Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Heterochromatin Formation Negative Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process P53 Binding Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Nucleosome Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Facultative Heterochromatin Formation Protein-containing Complex Heterochromatin Regulation Of DNA-templated Transcription Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Constitutive Heterochromatin Formation Chromatin Binding Intracellular Signal Transduction Regulation Of RNA Metabolic Process Protein-DNA Complex Assembly Chromosome Transferase Activity Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Multicellular Organismal Process DNA (cytosine-5-)-methyltransferase Activity Chromatin Silencing Complex Negative Regulation Of Cell Cycle DNA Binding Protein Modification Process Chromatin DNA Binding Positive Regulation Of Gene Expression	Nucleus Pronucleus Transcription Corepressor Binding Chromatin Silencing Complex
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