ERCC5 and EWSR1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ERCC5	EWSR1
Description		ERCC excision repair 5, endonuclease	EWS RNA binding protein 1
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Chromosome Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cajal Body Membrane
	Molecular Function	Bubble DNA Binding RNA Polymerase II Complex Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Enzyme Activator Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair DNA Recombination DNA Damage Response Response To UV Response To UV-C Negative Regulation Of Apoptotic Process	Regulation Of DNA-templated Transcription
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	Extraskeletal myxoid chondrosarcoma Myxoid liposarcoma Ewing's sarcoma Clear cell sarcoma of soft tissue
GWAS		Apolipoprotein A1 levels ( 32203549) Metabolite levels ( 23823483) Urinary calcium excretion ( 31993563)	Breast cancer ( 23535729) Pancreatic cancer ( 25086665) Platelet count ( 27863252) Platelet distribution width ( 32888494)
Interacting Genes		12 interacting genes: BRCA1 BRCA2 ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 HSPB1 NTHL1 PCNA POLR2A RAD51	164 interacting genes: ACTL6A AGT ANXA11 ARID1A ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BRME1 BTK C11orf16 CALM1 CCDC7 CCDC91 CD177 CDK12 CEACAM5 CEBPA CETP CFAP298 CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EPAS1 ERCC5 FAM131C FASN FLI1 FXR2 GNPDA1 GPBP1L1 H2BC15 HBP1 HDAC3 HERPUD1 HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 OGT PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B PTP4A2 RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SELENOI SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SMARCC1 SMARCC2 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383
Entrez ID		2073	2130
HPRD ID		00595	00592
Ensembl ID		ENSG00000134899	ENSG00000182944
Uniprot IDs		P28715	A0A0D9SFL3 Q01844
PDB IDs		5EKF 5EKG 6TUR 6TUS 6TUW 6TUX 6VBH	2CPE
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair DNA Repair DNA Metabolic Process DNA Damage Response Nuclear Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Transcription Factor TFIIH Core Complex Cellular Response To Stress Transcription Factor TFIIH Holo Complex Damaged DNA Binding Lateral Element Response To Radiation Nucleobase-containing Compound Metabolic Process Regulation Of DNA Damage Checkpoint Mitotic Recombination-dependent Replication Fork Processing Response To X-ray Nucleoplasm Transcription By RNA Polymerase II Response To Stress Response To Ionizing Radiation Replication Fork Processing Response To UV Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Male Germ Cell Nucleus Response To Gamma Radiation DNA-templated Transcription DNA-templated Transcription Elongation Nucleus Regulation Of Cell Cycle Phase Transition Transcription Elongation By RNA Polymerase I Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Metabolic Process Double-strand Break Repair Regulation Of DNA Repair DNA Binding Cellular Response To Ionizing Radiation Regulation Of Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Transcription-coupled Nucleotide-excision Repair Positive Regulation Of DNA Metabolic Process DNA Repair Complex Telomere Maintenance Via Recombination Telomere Maintenance Apoptotic Signaling Pathway Response To Light Stimulus Chromosome ATP-dependent DNA Damage Sensor Activity RNA Polymerase Binding Mitotic Recombination	Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Organization RNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Transcription Regulator Complex Chromatin Remodeling MRNA Metabolic Process Brahma Complex NpBAF Complex RNA Metabolic Process Regulation Of Gene Expression Nucleic Acid Binding Chromatin Single-stranded DNA Binding Protein-containing Complex Negative Regulation Of DNA-templated Transcription Cardiac Conduction System Development Chromatin Binding Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Binding MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Nucleosome Disassembly TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process
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