AKT1 and APOE

Number of citations of the paper that reports this interaction (PubMedID 34941261)
49

Data Source:
BioGRID (enzymatic study)

		AKT1	APOE
Description		AKT serine/threonine kinase 1	apolipoprotein E
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Spindle Cytosol Plasma Membrane Cell-cell Junction Cilium Cell Cortex Microtubule Cytoskeleton Membrane Lamellipodium Vesicle Protein-containing Complex Ciliary Basal Body Postsynapse Glutamatergic Synapse	Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Extracellular Matrix Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Discoidal High-density Lipoprotein Particle Melanosome Chylomicron Neuronal Cell Body Synaptic Cleft Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Multivesicular Body, Internal Vesicle Glutamatergic Synapse Extracellular Vesicle Lipoprotein Particle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Kinase Activity Transferase Activity Enzyme Binding Kinase Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding 14-3-3 Protein Binding Potassium Channel Activator Activity Protein Serine Kinase Activity TORC2 Complex Binding	Amyloid-beta Binding Signaling Receptor Binding Structural Molecule Activity Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Antioxidant Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Chelating Activity Protein Dimerization Activity Receptor Ligand Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Very-low-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Cholesterol Transfer Activity
	Biological Process	Osteoblast Differentiation Maternal Placenta Development Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Cytoplasmic Translation Complement Receptor Mediated Signaling Pathway Sphingosine-1-phosphate Receptor Signaling Pathway Glycogen Metabolic Process Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Glucose Metabolic Process Gluconeogenesis Translational Initiation Regulation Of Translation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Nitric Oxide Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Response To Oxidative Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Germ Cell Development Nervous System Development Cell Population Proliferation Insulin Receptor Signaling Pathway Apoptotic Mitochondrial Changes Cellular Response To Starvation Response To Heat Response To Hormone Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Fibroblast Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Sodium Ion Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Neuron Projection Development Negative Regulation Of Macroautophagy Phosphorylation Cell Migration Protein Ubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Mammalian Oogenesis Stage Cell Differentiation Protein Catabolic Process Positive Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Costimulation Negative Regulation Of Protein Ubiquitination Regulation Of Myelination Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Endodeoxyribonuclease Activity Response To Food Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Stress Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Amino Acid Starvation Response To Fluid Shear Stress Protein K29-linked Ubiquitination Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Decreased Oxygen Levels SREBP-SCAP Complex Retention In Endoplasmic Reticulum TRNA Stabilization Calcium Import Into The Mitochondrion PERK-mediated Unfolded Protein Response TORC1 Signaling Glucose Homeostasis Regulation Of Apoptotic Process Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Anoikis Regulation Of MRNA Stability Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Cilium Assembly Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Nitric Oxide Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Organ Growth Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Behavioral Response To Pain Positive Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Protein Maturation Excitatory Postsynaptic Potential Response To Growth Hormone Regulation Of Vesicle-mediated Transport Mammary Gland Epithelial Cell Differentiation Labyrinthine Layer Blood Vessel Development Protein Localization To Cilium Response To UV-A Response To Growth Factor Protein Localization To Endoplasmic Reticulum Protein K11-linked Ubiquitination Cellular Response To Calcium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Tricarboxylic Acid Metabolic Process Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Cellular Response To Rapamycin Protein K6-linked Ubiquitination Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Postsynapse Organization TRNA (guanine-N7)-methylation Regulation Of TRNA Methylation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus CGAS/STING Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Negative Regulation Of CGAS/STING Signaling Pathway Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Cellular Response To Peptide Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cilium Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Maturation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Nerve Growth Factor Stimulus Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Reactive Oxygen Species Negative Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Catabolic Process Lipid Transport Intracellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Response To Oxidative Stress Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Synaptic Transmission, Cholinergic Long-term Memory Steroid Metabolic Process Cholesterol Metabolic Process Gene Expression Regulation Of Gene Expression Negative Regulation Of Platelet Activation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Cholesterol Efflux Lipid Transport Involved In Lipid Storage Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Long-chain Fatty Acid Transport Protein Import Virion Assembly Negative Regulation Of Blood Coagulation Regulation Of Axon Extension Neuron Projection Development Melanosome Organization Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Efflux Phospholipid Efflux Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Very-low-density Lipoprotein Particle Clearance Locomotory Exploration Behavior Nitric Oxide-cGMP-mediated Signaling Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Vasodilation Cholesterol Homeostasis Regulation Of Apoptotic Process Amyloid Precursor Protein Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of MAPK Cascade Negative Regulation Of Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Host-mediated Activation Of Viral Process Regulation Of Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Endocytosis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Lipid Biosynthetic Process Intracellular Transport Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Smooth Muscle Cell Proliferation Artery Morphogenesis Negative Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Lipid Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Maintenance Of Location In Cell Lipid Homeostasis Fatty Acid Homeostasis Acylglycerol Homeostasis Artery Development Positive Regulation Of Dendritic Spine Development Negative Regulation Of Dendritic Spine Development Regulation Of Proteasomal Protein Catabolic Process Response To Caloric Restriction Triglyceride Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipoprotein Particle Stimulus Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Clearance Circulatory System Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cholesterol Metabolic Process Positive Regulation Of Cholesterol Metabolic Process Negative Regulation Of Triglyceride Metabolic Process Negative Regulation Of Cholesterol Efflux Regulation Of Plasma Lipoprotein Particle Levels AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Cellular Oxidant Detoxification Positive Regulation Of Lipoprotein Transport Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dendritic Spine Maintenance Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Phospholipid Efflux Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood-brain Barrier Positive Regulation Of Lipid Transport Across Blood-brain Barrier Cellular Response To Amyloid-beta Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Regulation Of Amyloid Fibril Formation Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Regulation Of Behavioral Fear Response
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Mitochondrial unfolded protein response (UPRmt) High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Nuclear signaling by ERBB4 Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs		ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol Archexin Enzastaurin Perifosine N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome	Alzheimer's disease (AD) Hyperlipoproteinemia, type III; Dysbetalipoproteinemia Lipoprotein glomerulopathy
GWAS		Apolipoprotein A1 levels ( 32203549) Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) HDL cholesterol ( 24097068 25961943 30275531) HDL cholesterol levels ( 28334899 32203549) Neutrophil count ( 32888494) Vitamin C levels ( 33203707)	Abdominal aortic aneurysm ( 32981348) Adult body size ( 32376654) Advanced age-related macular degeneration ( 26691988) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Age-related macular degeneration ( 23326517 23455636) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alanine aminotransferase levels ( 33547301) Alzheimer disease and age of onset ( 26830138) Alzheimer's disease ( 17975299 17998437 18823527 19125160 19734902 19734903 20061627 20460622 21627779 22245343 22832961 24755620 24770881 30636644 31473137 33074286) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 17474819 20885792 23565137 26339675 28714976 30617256) Alzheimer's disease (onset at age over 80) ( 30979435) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease biomarkers ( 21123754 23419831 23562540) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Alzheimer's disease progression score ( 29860282) Alzheimer’s disease (clinical subgroup AD+) ( 31473137) Alzheimer’s disease (clinical subgroup AD++) ( 31473137) Alzheimer’s disease (clinical subgroup AD+++) ( 31473137) Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD+) ( 31473137) Apolipoprotein A1 levels ( 32203549) Apolipoprotein Levels ( 23031429) Aspartate aminotransferase levels ( 33547301) Body fat percentage ( 26833246) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain imaging ( 20100581) C-reactive protein ( 18439548 18439552 19567438 23844046) C-reactive protein levels ( 29403010 29878111 30388399 33339817) Cardiovascular risk factors ( 20838585) Carotid intima media thickness ( 30510157) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid angiopathy in APOEe4 carrier Alzheimer’s disease ( 34020725) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487) Cerebral amyloid deposition positivity (PET imaging) ( 26252872) Cerebral microbleeds ( 32913026) Cerebral microbleeds (lobar) ( 32913026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 25027320 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 28641921 29274321 30319691) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691) Cerebrospinal fluid t-tau levels ( 28641921 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 30319691) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cholesterol, total ( 19060911 20686565 24097068 25961943 28270201) Cingulate cortical amyloid beta load ( 26421299) Cognitive decline ( 22054870) Cognitive decline (age-related) ( 24468470 28078323) Cognitive impairment test score ( 30319691) Coronary artery disease ( 26343387 29212778 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Dementia with Lewy bodies ( 29263008 31065058) Family history of Alzheimer's disease ( 30617256) Fasting triglyceride levels ( 32603185) Fish- and plant-related diet ( 32066663) Free cholesterol levels in large LDL ( 29084231) Fruit consumption ( 32066663) Gut microbiota (functional units) ( 27694959) HDL cholesterol ( 19060911 20686565 21909109 24097068 25961943 28270201 30275531) HDL cholesterol levels ( 26690388 28334899 32203549) HDL cholesterol levels in HIV infection ( 33109212) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Hippocampal atrophy ( 22745009) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Ideal cardiovascular health (clinical) ( 27179730) Immature fraction of reticulocytes ( 27863252) Lamb consumption ( 32066663) Late-onset Alzheimer's disease ( 29360470) LDL cholesterol ( 18193043 18193044 18802019 19060906 19060911 20686565 20864672 23067351 23726366 24097068 24507774 25961943 26160806) LDL cholesterol levels ( 17463246 26763881 28334899 28371326 31087446 32759990) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lewy body disease ( 25188341) Lipid metabolism phenotypes ( 22286219) Lipid or lipoprotein levels ( 23696881) Lipid traits ( 24023260 30576415) Lipoprotein (a) levels ( 28512139 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms ( 28512139) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease ( 28753643) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Lobar intracerebral hemorrhage ( 31430377) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Longevity ( 21418511 31484785) Longevity (100 years and older) ( 33948810) Longevity (85 years and older) ( 24688116) Longevity (90 years and older) ( 24688116) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Low density lipoprotein cholesterol levels ( 28548082 29403010 30718733 33339817) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antithrombotic agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Medication use (salicylic acid and derivatives) ( 31015401) Mental health study participation (completed survey) ( 31263887) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) Moderate to vigorous physical activity levels ( 29899525) Mortality ( 27029810) Myocardial infarction ( 33532862) Neuritic plaque ( 31497858) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles (pleiotropy) ( 29458411) Neurofibrillary tangles ( 31497858) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Nonalcoholic fatty liver disease ( 34841290) Parental lifespan ( 29030599 30642433) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's age at death or mother's attained age) ( 31484785) Parental longevity (mother's age at death) ( 29227965 31484785) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease progression (cognitive) ( 33111402) Parkinson's disease progression (composite) ( 33111402) Percent liver fat ( 34128465) Plasma amyloid beta peptide concentration (ABx-40/ABx-42 ratio) ( 34002480) Plasma amyloid beta peptide concentrations (ABx-42) ( 34002480) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Postprandial triglyceride levels ( 32603185) Psychosis and Alzheimer's disease ( 22005930) Pulse pressure ( 30224653 30578418) Quantitative traits ( 19197348) Red cell distribution width ( 27863252 28957414 32888494) Refractive error ( 32231278) Relative sugar intake ( 32393786) Response to statins (LDL cholesterol change) ( 22331829 25350695) Resting heart rate ( 27798624) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum C-reactive protein concentration ( 32928877) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum total cholesterol levels ( 29084231 33134509) Serum type 1 collagen metabolite levels ( 33134509) Systolic blood pressure ( 30578418) Total cholesterol levels ( 26690388 28334899 28548082 29403010 30718733 31087446 32759990 33339817) Total cholesterol levels in LDL ( 29084231) Triglyceride levels ( 28334899 29403010 30718733 33339817) Triglyceride levels in HIV infection ( 33109212) Triglycerides ( 19060911 20686565 24507774 25961943 26582766) Type 2 diabetes ( 27189021 28869590 30297969) Verbal declarative memory ( 25648963) Verbal memory performance (immediate recall change) ( 28800603) Verbal memory performance (residualized delayed recall level) ( 28800603) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Vigorous physical activity ( 29899525) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		401 interacting genes: ABI1 ABRAXAS1 ACAP1 ACAT2 ADCY10 AGAP2 AGR3 AHNAK AHSA1 AKT1S1 AKT2 AKTIP ALYREF AMBRA1 APLP2 APOC1 APOE APOH APP APPL1 AR ARAF ARFIP2 ARHGAP9 ARHGEF16 ARHGEF28 ARNT ATXN1 AURKA BABAM1 BAD BAG6 BCL10 BCL2L1 BCL2L11 BCL3 BECN1 BEX1 BLVRA BPGM BRAF BRCA1 BTRC BUB1 C1orf174 CAMKK1 CARHSP1 CASC3 CASP3 CASP9 CASTOR1 CBLC CCDC88A CCND2 CCNE1 CCNF CCNI CCT2 CD44 CDC37 CDC42 CDH1 CDK1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CEP57L1 CEP76 CGGBP1 CHEK1 CHUK CLASP2 CLIP3 CLK2 CMTM8 CNKSR3 CNOT9 CREB1 CREBBP CSNK2A1 CTDP1 CTDSP2 CTNNA1 CTNNB1 CYLD DAB2IP DCTN1 DDIT4L DLC1 DNAJB1 DNMT1 EEF1G EFHC1 EIF4EBP1 ELAVL1 EMSY ENO2 EP300 EPHA2 EPSTI1 ERBB2 ESR1 ESR2 EZH2 FAF1 FAM168A FANCA FANCI FASN FBXO31 FBXW7 FGFR4 FOXO1 FOXO3 FOXO4 FUS FXN GAB1 GAB2 GATA1 GATA2 GET4 GFAP GJA1 GLIS2 GMPPA GPT2 GRB10 GRIN2A GSK3A GSK3B H2BC21 H2BC3 HEATR3 HIF1A HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB IL13RA2 IL24 ILK IMPDH2 IRAK1 IRS1 ISCA2 ITCH ITGB3 ITPKB ITPR1 ITPR3 ITSN1 IWS1 JADE1 KANK1 KAT2A KAT2B KAT6A KDELR2 KLHL3 KLRC1 KMT2D KRT10 LANCL2 LATS2 LRRK2 LTB4R2 MAGEB1 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K11 MAP3K5 MAP3K8 MAPK4 MAPK8 MAPK8IP1 MAPK9 MAPKAP1 MAPKAPK2 MAPT MARK4 MATK MDM2 MDM4 MEF2D MESD METTL1 MIS12 MLF2 MLH3 MOK MRC2 MS4A2 MSH2 MST1R MTA3 MTCP1 MTOR MTUS2 MUL1 MXD1 MYC NCF2 NCKIPSD NCOA4 NCOR2 NEDD4 NEDD4L NF1 NF2 NGB NHERF1 NIBAN1 NKD1 NLGN3 NOL4 NOS3 NOTCH1 NR4A1 NRAS NRIP2 NSD3 OFD1 OSBPL11 OSGIN1 OTUD1 OXSR1 PAK1 PCGF2 PCK1 PDE3A PDE3B PDGFRA PDHB PDK1 PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PFKP PHB2 PI4K2B PIAS1 PIAS2 PICK1 PIK3CA PIK3R1 PIP5K1C PKN2 PLCG1 PLEKHO1 PLP1 PLXNA1 PMS2 POP4 POP7 PPARGC1B PPL PPM1A PPM1H PPP1CA PPP1R11 PPP2CA PPP2R1A PRG2 PRKAR1A PRKCQ PRKCZ PRKDC PSMC5 PSRC1 PTEN PTGDS PTPA PTPN1 PTPN11 PTPN3 PYCR3 PYGO2 RAB3D RAC1 RAF1 RAP1GDS1 RARA RASL10B RASSF1 REPS1 REX1BD RGCC RHEBL1 RNF11 RNF115 RPS6KB1 RUVBL2 S100A14 S1PR1 SERPINB5 SETDB1 SFMBT2 SH2B2 SH3RF1 SHANK2 SHQ1 SIRPA SIRT1 SIRT6 SKI SKP2 SLFN5 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SNCB SORBS1 SORBS2 SOX4 SP1 SP3 SPACA6 SPATA33 SRC SRPK2 SRR SSH1 ST14 STAT1 STK11 STK3 STK4 STOX1 SULT4A1 SUPT6H SYTL1 TBC1D4 TBC1D7 TBCE TCL1A TCL1B TCL6 TEAD2 TERF2IP TERT TFF1 THEM4 THRSP TLR2 TMCC2 TNFRSF1A TNFSF11 TNK2 TOPBP1 TP53 TRAF6 TRIB3 TRIM13 TRIM24 TRIT1 TRMT2B TSC1 TSC2 TTC3 UBE2S UCHL1 UHRF1 URI1 USP10 USP4 USP50 UXS1 VEGFA VHL VIM WDR53 WEE1 WNK1 WNK4 XAF1 XIAP YAP1 YBX1 YIF1B YWHAZ ZC3HAV1 ZFP36L1 ZHX1 ZNF691 ZRANB1	68 interacting genes: A2M ACE2 AKT1 ALB ANKH APOC2 APOC4 APP ARFGAP1 CD1D CD79A CDC37 CEACAM1 CNTF CSNK2A1 CST1 CTSB CYP2C18 CYP2C8 ECSIT ELAVL1 EPN2 FARSA FBXL12 FOXG1 FXYD7 GCDH HSP90AA1 HTRA1 IFIT3 IFIT5 IQSEC1 LCAT LDLR LINC02582 LONP1 LOXL4 LRP1 LRP2 LRP8 MAP2 MAPT MAST1 MID1IP1 NEFM NOS3 PCMT1 PDCD4 PLEKHA6 PLTP PRAM1 PRDX2 PRNP PSEN1 RHEB RNF32 RPL4 S100B SCARB1 SNCA SORL1 ST13 TIMM29 TREM2 TYRO3 VLDLR ZBP1 ZNF558
Entrez ID		207	348
HPRD ID		01261	00135
Ensembl ID		ENSG00000142208	ENSG00000130203
Uniprot IDs		B0LPE5 B3KVH4 P31749	A0A0S2Z3D5 P02649
PDB IDs		1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV 6BUU 6CCY 6HHF 6HHG 6HHH 6HHI 6HHJ 6NPZ 6S9W 6S9X 7APJ 7MYX 7NH4 7NH5 8JOW 8UVY 8UW2 8UW7 8UW9 8ZPU	1B68 1BZ4 1EA8 1GS9 1H7I 1LE2 1LE4 1LPE 1NFN 1NFO 1OEF 1OEG 1OR2 1OR3 2KC3 2KNY 2L7B 6IWB 6NCN 6NCO 7FCR 7FCS 7UVJ 8AX8 8AX9 8CDY 8CE0 8GRX
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Cytosol Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Stress Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Developmental Process Positive Regulation Of Protein Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Kinase Activity Cellular Response To Oxygen-containing Compound Regulation Of Cell Cycle Protein Kinase Activity Regulation Of Protein Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Protein Modification Process Regulation Of Phosphorus Metabolic Process MAPK Cascade Protein Serine Kinase Activity Protein Kinase Binding Regulation Of Protein Modification Process Regulation Of Apoptotic Signaling Pathway	Apolipoprotein Binding Low-density Lipoprotein Particle Receptor Activity Astrocyte Activation Low-density Lipoprotein Particle Binding Positive Regulation Of Protein Catabolic Process High-density Lipoprotein Particle Endocytosis Memory Positive Regulation Of Catabolic Process Amyloid-beta Metabolic Process Regulation Of Multicellular Organismal Process Amyloid-beta Binding High-density Lipoprotein Particle Binding Regulation Of Defense Response Import Into Cell Regulation Of Nervous System Development Regulation Of Innate Immune Response Regulation Of Protein Catabolic Process Astrocyte Activation Involved In Immune Response Very-low-density Lipoprotein Particle Receptor Activity Regulation Of Apoptotic Process Receptor-mediated Endocytosis Retinoid Metabolic Process Main Axon Apolipoprotein A-I Binding Positive Regulation Of Lysosomal Protein Catabolic Process Very-low-density Lipoprotein Particle Binding Diterpenoid Metabolic Process Regulation Of Programmed Cell Death Regulation Of Amyloid Fibril Formation Regulation Of Immune Response Negative Regulation Of Signaling Very-low-density Lipoprotein Particle Receptor Complex Neuronal Cell Body Regulation Of Vesicle-mediated Transport Negative Regulation Of Signal Transduction Regulation Of Neurogenesis Cellular Response To Amyloid-beta Terpenoid Metabolic Process Regulation Of Phospholipid Catabolic Process High-density Lipoprotein Particle Clearance Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Phosphorus Metabolic Process Molecular Function Activator Activity Cargo Receptor Activity Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Protein Metabolic Process Protein-folding Chaperone Binding Isoprenoid Metabolic Process
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