NR2F6 and CBX1

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		NR2F6	CBX1
Description		nuclear receptor subfamily 2 group F member 6	chromobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Heterochromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Chromocenter Nuclear Body Site Of DNA Damage
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Protein Binding Enzyme Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Nervous System Development Cell Differentiation Intracellular Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Neuron Development Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain	DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways		Nuclear Receptor transcription pathway	HCMV Early Events
Drugs
Diseases
GWAS		Mitochondrial DNA copy number ( 30704525) Night sleep phenotypes ( 27126917)	Aspartate aminotransferase levels ( 33547301) Body mass index ( 20935630 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Generalized epilepsy ( 22949513)
Interacting Genes		13 interacting genes: ANGPTL1 BCL11A CBX1 ESR1 NAP1L1 NCOA1 NR2F2 NR3C1 NSD1 RAB8A RARG RXRA THRB	36 interacting genes: ABI3BP ARL5A ATXN7L2 BAHD1 BARD1 BRCA1 CBX3 CBX5 CHAF1A DCAF7 DNMT1 DNMT3A DNMT3B EMSY H1-4 H3-4 H3C1 H3C3 HECW2 HSPB1 KLF11 LNX1 LRIF1 NR2F6 PCNA PIM1 RPL12 SP100 SUV39H1 TBKBP1 TRIM24 TRIM28 UCHL1 VHL VTN ZNF280C
Entrez ID		2063	10951
HPRD ID		00583	05149
Ensembl ID		ENSG00000160113	ENSG00000108468
Uniprot IDs		F1D8R3 P10588	P83916 Q6IBN6
PDB IDs			2FMM 3F2U 3Q6S 5T1G 6D07 6D08
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Chromatin Regulation Of Thyroid Hormone Receptor Signaling Pathway Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Retinoid X Receptor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Reproductive Behavior Sequence-specific Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex Nuclear Estrogen Receptor Binding Cellular Response To Hormone Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process MRNA Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Reproductive Structure Development MRNA Transcription Response To Lipid Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Female Receptivity Female Mating Behavior Regulation Of RNA Metabolic Process Chromatin Organization Zinc Ion Binding Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Negative Regulation Of Metabolic Process	Chromatin Organization Heterochromatin Chromatin Remodeling Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA (cytosine-5-)-methyltransferase Activity Nucleoplasm Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Euchromatin Chromo Shadow Domain Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Programming Of Gene Expression Negative Regulation Of Biosynthetic Process Ubiquitin-protein Transferase Activity Chromosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Regulation Of Primary Metabolic Process DNA Damage Response Nucleosome Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleus Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Macromolecule Metabolic Process BRCA1-BARD1 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Metabolic Process Nucleosome Organization DNA Binding Cellular Response To Stress DNA-methyltransferase Activity BRCA1-B Complex Cellular Response To Bisphenol A Structural Constituent Of Chromatin Pericentric Heterochromatin Post-translational Protein Modification Protein-DNA Complex Assembly
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