EPHA8 and ZNF746

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		EPHA8	ZNF746
Description		EPH receptor A8	zinc finger protein 746
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Dendrite Early Endosome Membrane Cell Projection Neuron Projection	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Growth Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Substrate-dependent Cell Migration Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Neuron Remodeling Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Follicle-stimulating Hormone Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization Protein Heterooligomerization
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Generic Transcription Pathway
Drugs		Fostamatinib
Diseases
GWAS		Serum alkaline phosphatase levels ( 33547301)	Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)
Interacting Genes		12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746	15 interacting genes: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K20 MAP3K7 PRKN PRKRA RPS6KA6 UBE2E3 ZNF777
Entrez ID		2046	155061
HPRD ID		01493	08099
Ensembl ID		ENSG00000070886	ENSG00000181220
Uniprot IDs		P29322	A0A2R8YDQ5 A0A8J9FQ52 Q6NUN9
PDB IDs		1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway ATP Binding Neuron Projection Guidance Axon Guidance Nucleotide Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Synapse Organization Side Of Membrane Signaling Receptor Binding Regulation Of Postsynapse Organization Synaptic Membrane Adhesion Regulation Of Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Dendritic Spine Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Organization Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Regulation Of Cell Morphogenesis Cellular Response To Glycine Response To Singlet Oxygen Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Modification Process Positive Regulation Of Synapse Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Nucleoside Triphosphate Adenylate Kinase Activity Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of Phosphate Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T Cell Proliferation Response To Glycine Nuclear Proteasome Complex DNA/RNA Helicase Activity Aspartyl-tRNA Aminoacylation	Protein Kinase Activity ATP Binding Kinase Activity Protein Serine/threonine Kinase Activity Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Transferase Activity Magnesium Ion Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Protein Phosphorylation Protein Autophosphorylation Protein Serine Kinase Activity P38MAPK Cascade Stress-activated MAPK Cascade MAP Kinase Kinase Kinase Activity Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Gene Expression Phosphorylation Signal Transduction In Response To DNA Damage Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Autophagy Protein Kinase Binding Protein K11-linked Ubiquitination Protein Kinase Activator Activity Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Spontaneous Neurotransmitter Secretion Positive Regulation Of Mitotic DNA Damage Checkpoint Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Modification Process Cytosol Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Stress Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Glycogen (starch) Synthase Activity Scaffold Protein Binding Heme Oxidation Heme Oxygenase (decyclizing) Activity Positive Regulation Of Retrograde Transport, Endosome To Golgi Protein Monoubiquitination Negative Regulation Of Intralumenal Vesicle Formation
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