STOM and ASIC2

Number of citations of the paper that reports this interaction (PubMedID 15471860)
0

Data Source:
HPRD (in vivo)

		STOM	ASIC2
Description		stomatin	acid sensing ion channel subunit 2
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Membrane Specific Granule Membrane Melanosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Membrane Blood Microparticle	Plasma Membrane Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Density Membrane
	Molecular Function	Protein Binding Ion Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity RNA Polymerase Binding	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity PH-gated Sodium Channel Activity
	Biological Process	Regulation Of Monoatomic Ion Transmembrane Transport Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Protein Targeting To Membrane	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Synapse Assembly Phototransduction Sensory Perception Of Sound Response To Mechanical Stimulus Response To Acidic PH Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Establishment Of Localization In Cell Positive Regulation Of Synapse Assembly Cellular Response To Xenobiotic Stimulus Cellular Response To Acidic PH Regulation Of Postsynapse Assembly
Pathways		Stimuli-sensing channels Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle	Stimuli-sensing channels
Drugs			Amiloride
Diseases		Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS			Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Autism ( 30675382) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Congenital heart disease (septal defects) ( 33201861) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 26912274) Mosquito bite size ( 28199695) Plasma parathyroid hormone levels ( 30134803) Polycystic ovary syndrome ( 30343302) Serum bilirubin levels in metabolic syndrome ( 30621171) Severe gingival inflammation ( 28459102)
Interacting Genes		89 interacting genes: AIG1 APOA2 ASIC1 ASIC2 ASIC3 ASS1 ATP1B3 ATP6V0B ATP6V0C BCL2L2 BNIP1 C2 C3orf52 CFHR5 CHST1 CLDN19 CLRN2 CMTM5 CNIH3 CRAT CTXN3 CYB5B CYB5R3 DAGLA DVL3 EMP1 ERG28 FAXDC2 FPGS FUNDC2 GIMAP1 GIMAP5 GPR25 GPR37L1 GRM2 HMOX2 KCNK1 KTN1 LANCL1 LNPEP MGLL MMP14 MT2A NKG7 NUP214 ORMDL1 PEDS1-UBE2V1 PEMT PGA4 PMP22 PSMB7 PTCH1 RPL13A RPRM RTP2 RUVBL1 RUVBL2 SCD SELENOK SERP2 SFT2D1 SFT2D2 SFXN1 SFXN5 SLC2A1 SLC35B4 SMCO4 STX6 STXBP1 TECR THSD7B TMEM109 TMEM120B TMEM140 TMEM14B TMEM203 TMEM208 TMEM254 TMEM60 TMEM86B TMEM98 TMPO TNF TNFRSF10C TSPO2 VAMP4 VAV2 WFDC2 YIPF6	5 interacting genes: ASIC1 ASIC3 PICK1 SMG6 STOM
Entrez ID		2040	40
HPRD ID		00585	03471
Ensembl ID		ENSG00000148175	ENSG00000108684
Uniprot IDs		F8VSL7 P27105	Q16515
PDB IDs		7WH3	6L6P
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Sensory Perception Of Sour Taste Endoplasmic Reticulum Response To Acidic PH Sodium Channel Activity PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Ligand-gated Sodium Channel Activity Protein Binding Cellular Response To Type II Interferon Response To PH PH-gated Monoatomic Ion Channel Activity Nitric-oxide Synthase Complex Synaptic Vesicle To Endosome Fusion Mitochondrial Outer Membrane Response To Type II Interferon Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Nitrite Reductase (NO-forming) Activity R2TP Complex Cellular Response To PH Detection Of Mechanical Stimulus Involved In Sensory Perception Acylglycerol Catabolic Process Diacylglycerol Catabolic Process Lipid Biosynthetic Process Amino Acid Transport Organic Anion Transport Telomerase RNA Localization To Cajal Body Sensory Perception Of Taste Response To Mechanical Stimulus Plasma Membrane	PH-gated Monoatomic Ion Channel Activity Sensory Perception Of Sour Taste Ligand-gated Sodium Channel Activity Response To Acidic PH Sensory Perception Of Taste Sodium Channel Activity Monoatomic Cation Channel Activity Response To PH Establishment Of Localization In Cell Enterobactin Transport Enterobactin Transmembrane Transporter Activity Sensory Perception Of Chemical Stimulus Sodium Ion Transmembrane Transport Monoatomic Ion-gated Channel Activity PH-gated Sodium Channel Activity Siderophore Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Sodium Ion Transport Membrane Curvature Sensor Activity Plasma Membrane Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Neurotransmitter Secretion Inorganic Cation Transmembrane Transporter Activity Negative Regulation Of Actin Nucleation Negative Regulation Of Telomere Capping Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Neuronal Ion Channel Clustering Dendritic Spine Maintenance Ion Channel Inhibitor Activity Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Arp2/3 Complex Binding Regulation Of Telomere Capping Long-term Synaptic Depression Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Sensory Perception Regulation Of Transport Cellular Response To PH Regulation Of Membrane Potential Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Targeting To Membrane RNA Polymerase Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Involved In Sensory Perception Detection Of Temperature Stimulus Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Exon-exon Junction Complex Telomerase RNA Binding Telomeric DNA Binding
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