AK2 and ABCC5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AK2	ABCC5
Description		adenylate kinase 2	ATP binding cassette subfamily C member 5
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Sperm Flagellum Extracellular Exosome Sperm Mitochondrial Sheath	Endosome Golgi Apparatus Golgi Lumen Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Nucleotide Binding AMP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Nucleobase-containing Compound Kinase Activity	Nucleotide Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Purine Nucleotide Transmembrane Transporter Activity Heme Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Macromolecule Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity Carbohydrate Derivative Transmembrane Transporter Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process ADP Biosynthetic Process Nucleotide Metabolic Process Nucleoside Monophosphate Metabolic Process Nucleobase-containing Small Molecule Interconversion AMP Metabolic Process ATP Metabolic Process Nucleoside Monophosphate Phosphorylation	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Purine Nucleotide Transport Hyaluronan Biosynthetic Process Glutathione Transmembrane Transport Heme Transmembrane Transport Xenobiotic Transport Transmembrane Transport CAMP Transport CGMP Transport Monoatomic Anion Transmembrane Transport Folate Transmembrane Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Interconversion of nucleotide di- and triphosphates	Hyaluronan metabolism ABC-family proteins mediated transport Azathioprine ADME Paracetamol ADME
Drugs		Bis(Adenosine)-5'-Pentaphosphate Imidazole	Curcumin Curcumin sulfate
Diseases
GWAS		Gut microbiota (beta diversity) ( 27723756)	Anterior chamber depth ( 24603532) Basophil percentage of white cells ( 32888494) Eosinophil count ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: ABCC5 ABCC6 SHBG TRIM54	5 interacting genes: AK2 RBP5 SERPINA3 SMC2 TIAM1
Entrez ID		204	10057
HPRD ID		00047	06898
Ensembl ID		ENSG00000004455	ENSG00000114770
Uniprot IDs		A0A140VK93 F8VY04 F8W1A4 G3V213 P54819	O15440
PDB IDs		2C9Y	8KCI 8WI2 8WI3 8WI4 8WI5
Enriched GO Terms of Interacting Partners?		ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Adenine Nucleotide Transport Purine Nucleotide Transport ATPase-coupled Transmembrane Transporter Activity Nucleotide Transport ABC-type Transporter Activity Carbohydrate Derivative Transport Carbohydrate Derivative Transmembrane Transporter Activity CGMP Transport Macromolecule Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Organophosphate Ester Transport Monoatomic Anion Transport CAMP Transport Heme Transmembrane Transport Folate Transmembrane Transport Purine Nucleotide Transmembrane Transporter Activity Inorganic Diphosphate Transport Nucleobase-containing Compound Transport Inhibition Of Non-skeletal Tissue Mineralization Hyaluronan Biosynthetic Process Basolateral Plasma Membrane Androgen Binding Organic Acid Transport Carboxylic Acid Transport Leukotriene Transport Glutathione Transmembrane Transporter Activity Heme Transmembrane Transporter Activity Heme Transport ABC-type Glutathione S-conjugate Transporter Activity Response To Sodium Phosphate Intracellular Phosphate Ion Homeostasis Folic Acid Transport Cyclic Nucleotide Transport Glutathione Transmembrane Transport Organic Anion Transport Efflux Transmembrane Transporter Activity Glutathione Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane ATP Hydrolysis Activity Xenobiotic Export From Cell ABC-type Xenobiotic Transporter Activity Oligopeptide Transmembrane Transport Xenobiotic Transmembrane Transport Response To Magnesium Ion Oligopeptide Transport Iron Ion Transmembrane Transport Glycosaminoglycan Biosynthetic Process Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity	Extracellular Exosome ADP Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Nucleoside Monophosphate Phosphorylation Sperm Mitochondrial Sheath Nucleobase-containing Compound Kinase Activity Phosphotransferase Activity, Phosphate Group As Acceptor AMP Kinase Activity Condensin Complex Meiotic Chromosome Condensation Positive Regulation Of Chromosome Condensation Nucleoside Diphosphate Biosynthetic Process Ribonucleoside Diphosphate Biosynthetic Process Lipid Binding Regulation Of Dopaminergic Neuron Differentiation Meiotic Chromosome Segregation Regulation Of Chromosome Condensation Retinol Binding Retinal Binding Retinoid Binding Mitotic Chromosome Condensation Kinetochore Organization
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