TMEM31 and TNFRSF10B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM31	TNFRSF10B
Description		transmembrane protein 31	TNF receptor superfamily member 10b
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding	Death Receptor Activity Protein Binding TRAIL Receptor Activity Signaling Receptor Activity TRAIL Binding
	Biological Process		Defense Response To Tumor Cell Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus
Pathways			Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
Drugs			HGS-TR2J Lexatumumab
Diseases
GWAS			Blood protein levels ( 30072576) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Renal cell carcinoma ( 28598434)
Interacting Genes		138 interacting genes: ABHD16A ABHD5 AGPAT4 AGTRAP ANKRD46 APOD ARV1 ATP6V0C BCAP31 BLCAP BMP10 BNIP1 BTN2A2 C14orf180 C2CD2L CAMLG CCL4 CGRRF1 CLDND2 CLN5 CLRN1 CMTM7 CNIH3 COX14 COX20 CTSA CTXN3 CXCL9 CXorf66 CYB561A3 CYB5R3 DEFB103A DEFB103B DEFB105A DEFB105B DERL1 DERL3 DGAT2L6 DHRSX DNAJC30 EBP EHHADH EMP1 ERG28 FAXDC2 FCER1G FKBP8 FXYD6 GIMAP5 GJB2 GJD4 GPR151 GUCA2A GYPA HERPUD2 HIGD1C HSD17B13 HSD3B7 IFITM5 ITGAM LHFPL5 LPAR3 LRAT LY6D MALL MMP14 MS4A1 NAT8 NINJ1 NINJ2 NSDHL ORMDL2 OTOP3 OTULINL PEDS1-UBE2V1 PLN PLP1 PLP2 PMP22 PNLIPRP1 PTPN1 RDH11 REEP2 RETREG3 RNF144A RNF19B RTP2 SELENOK SELENOM SERP2 SGTA SLC30A8 SLC35E4 SLC35H1 SLC39A6 SLC41A1 SLC66A2 SLC71A2 SLC7A14 SMAGP SMIM1 SMIM3 SMPD2 SNORC SPTSSA STX12 STX5 SYNGR1 TEX264 TIMMDC1 TMBIM6 TMEM107 TMEM121 TMEM14A TMEM14C TMEM182 TMEM203 TMEM208 TMEM218 TMEM239 TMEM242 TMEM254 TMEM255B TMEM44 TMEM50A TMEM86A TMX2 TNFRSF10B TRARG1 TSPAN2 TVP23B UBE2J1 VAMP2 VAMP3 VAMP5 YIF1A YIPF6 ZFPL1	17 interacting genes: ASPH CASP8 CDC42 CFLAR FADD KCNQ3 MADD MUC1 PCM1 RIPK1 TIMM50 TMEM31 TNFRSF10A TNFRSF10D TNFSF10 TRADD ZDHHC15
Entrez ID		203562	8795
HPRD ID		06652	04680
Ensembl ID		ENSG00000179363	ENSG00000120889
Uniprot IDs		A0A140VK58 Q5JXX7	O14763
PDB IDs			1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2 6NHW 6NHY 6T3J 8DPX
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Sterol Biosynthetic Process Lipid Biosynthetic Process Response To Endoplasmic Reticulum Stress Steroid Biosynthetic Process SNAP Receptor Activity Lipid Droplet Lipid Metabolic Process Endoplasmic Reticulum Unfolded Protein Response SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Bleb Assembly Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Mitochondrial Membrane Regulation Of Retrograde Protein Transport, ER To Cytosol Organelle Membrane Fusion Cholesterol Biosynthetic Process 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Establishment Of Protein Localization To Membrane Regulation Of Cellular Localization Regulation Of Intracellular Transport Membrane Destabilizing Activity Cellular Response To Unfolded Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Sterol Metabolic Process Mitochondrial Respiratory Chain Complex Assembly Organelle Fusion Response To Unfolded Protein Regulation Of Protein Exit From Endoplasmic Reticulum Membrane Organization	Death-inducing Signaling Complex TRAIL-activated Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Death Receptor Binding Ripoptosome Extrinsic Apoptotic Signaling Pathway Apoptotic Process Cell Death Programmed Cell Death TRAIL Binding Apoptotic Signaling Pathway CD95 Death-inducing Signaling Complex Regulation Of Necroptotic Process Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Differentiation Positive Regulation Of Programmed Cell Death Negative Regulation Of Necroptotic Process Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death Regulation Of Apoptotic Signaling Pathway Regulation Of Macrophage Differentiation Death Domain Binding Tumor Necrosis Factor Receptor Binding Positive Regulation Of Intracellular Signal Transduction Death Effector Domain Binding Macrophage Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Necroptotic Signaling Pathway Response To Mechanical Stimulus Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Signal Transduction Signaling Adaptor Activity Regulation Of Cell Communication Signal Transduction Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Positive Regulation Of Myeloid Cell Differentiation
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