EPB41 and SPTAN1

Number of citations of the paper that reports this interaction (PubMedID 12049649)
29

Data Source:
HPRD (in vivo)

		EPB41	SPTAN1
Description		erythrocyte membrane protein band 4.1	spectrin alpha, non-erythrocytic 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Cytoskeletal Protein Binding Spectrin Binding Phosphoprotein Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Regulation Of Calcium Ion Transport Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex	Actin Cytoskeleton Organization Actin Filament Capping
Pathways		Neurexins and neuroligins	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Hereditary elliptocytosis (HE)	Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) HDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		40 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CLNS1A CPAP CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RNF10 RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10	63 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 C5 CAPN1 CASP3 CASP7 CEP63 CNTRL CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TRAF1 TSSC4 TTC3 ZNF333
Entrez ID		2035	6709
HPRD ID		00558	01684
Ensembl ID		ENSG00000159023	ENSG00000197694
Uniprot IDs		A0A2R8Y5G2 A0A2R8Y5Z6 A0A2R8Y6D0 A0A2R8Y7Y3 A0A2R8YD30 A0A2U3TZH6 A0A994J847 P11171 Q1WWM3 Q29RX4 Q59F12	A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813
PDB IDs		1GG3 2RQ1 3QIJ	2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Spectrin Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Cortical Cytoskeleton Protein-containing Complex GMP Kinase Activity Muscle System Process Astral Microtubule Organization GDP Metabolic Process Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization Cell Junction Negative Regulation Of Cytosolic Calcium Ion Concentration Muscle Contraction Ankyrin Binding Regulation Of Neurotransmitter Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Intracellular Signaling Cassette Cytoskeletal Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Actin Filament Organization Regulation Of Transport GMP Metabolic Process Regulation Of Monoatomic Ion Transport Positive Regulation Of Supramolecular Fiber Organization Regulation Of Potassium Ion Transport Cytosol Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Actin Filament Capping Regulation Of Cellular Component Organization Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Pre-mRNA 3'-splice Site Binding U2AF Complex System Process Cadherin Binding Positive Regulation Of Transport Actin Filament Binding Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Cell Cycle Ankyrin-1 Complex Extracellular Exosome Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization	Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite
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