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EP300 and PAK2
Number of citations of the paper that reports this interaction (PubMedID
20936779
)
36
Data Source:
BioGRID
(two hybrid)
EP300
PAK2
Description
EP300 lysine acetyltransferase
p21 (RAC1) activated kinase 2
Image
GO Annotations
Cellular Component
Histone Acetyltransferase Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Cytoplasm
Cytosol
Protein-containing Complex
Protein-DNA Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Postsynaptic Density
Membrane
Nuclear Speck
Secretory Granule
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Molecular Function
Transcription Coregulator Binding
Transcription Coactivator Binding
P53 Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Histone Acetyltransferase Activity
L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Histone H3 Acetyltransferase Activity
Histone H4 Acetyltransferase Activity
Acetyltransferase Activity
Transferase Activity
Acyltransferase Activity
Nuclear Receptor Binding
Chromatin DNA Binding
Histone H3K18 Acetyltransferase Activity
Histone H2B Acetyltransferase Activity
Histone H3K27 Acetyltransferase Activity
Metal Ion Binding
Tau Protein Binding
Nuclear Androgen Receptor Binding
NF-kappaB Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Protein-lysine-acetyltransferase Activity
Protein Propionyltransferase Activity
Pre-mRNA Intronic Binding
STAT Family Protein Binding
Peptide 2-hydroxyisobutyryltransferase Activity
Peptide Lactyltransferase (CoA-dependent) Activity
Histone Lactyltransferase (CoA-dependent) Activity
Acetylation-dependent Protein Binding
Peptide Crotonyltransferase Activity
Peptide Butyryltransferase Activity
Histone Crotonyltransferase Activity
Histone Butyryltransferase Activity
DNA-binding Transcription Factor Binding
Histone Reader Activity
Histone H3K122 Acetyltransferase Activity
Nucleotide Binding
Catalytic Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Tyrosine Kinase Activator Activity
Small GTPase Binding
Identical Protein Binding
Cadherin Binding
Protein Serine Kinase Activity
Biological Process
Autophagosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Somitogenesis
Thigmotaxis
Behavioral Defense Response
Stimulatory C-type Lectin Receptor Signaling Pathway
Gluconeogenesis
Glycolytic Process
Regulation Of Glycolytic Process
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Protein Acetylation
Internal Protein Amino Acid Acetylation
Apoptotic Process
Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Learning Or Memory
Circadian Rhythm
Lipid Biosynthetic Process
Animal Organ Morphogenesis
Regulation Of Autophagy
Negative Regulation Of Autophagy
Positive Regulation Of Gene Expression
Regulation Of Mitochondrion Organization
Positive Regulation Of Neuron Projection Development
N-terminal Peptidyl-lysine Acetylation
Internal Peptidyl-lysine Acetylation
B Cell Differentiation
Platelet Formation
Lung Development
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein-containing Complex Assembly
Protein Destabilization
Cellular Response To Nutrient Levels
Negative Regulation Of Protein Oligomerization
Cellular Response To UV
Multicellular Organism Growth
Megakaryocyte Development
Endodermal Cell Differentiation
Swimming
TORC1 Signaling
TORC2 Signaling
Positive Regulation Of Protein Import Into Nucleus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Response To Estrogen
Host-mediated Activation Of Viral Transcription
Fat Cell Differentiation
Negative Regulation Of Gluconeogenesis
Transcription Initiation-coupled Chromatin Remodeling
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Rhythmic Process
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Canonical Wnt Signaling Pathway
Face Morphogenesis
Regulation Of Androgen Receptor Signaling Pathway
Peptidyl-lysine Propionylation
Protein Localization To Chromatin
Cellular Response To L-leucine
Tricarboxylic Acid Metabolic Process
T-helper 17 Cell Lineage Commitment
Regulation Of Tubulin Deacetylation
Peptidyl-lysine Crotonylation
Peptidyl-lysine Butyrylation
Regulation Of Cellular Response To Heat
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of TORC1 Signaling
Positive Regulation Of TORC2 Signaling
Positive Regulation Of T-helper 17 Cell Lineage Commitment
Stimulatory C-type Lectin Receptor Signaling Pathway
Cardiac Muscle Hypertrophy
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Starvation
Cell Migration
Adherens Junction Assembly
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of MAPK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Protein Maturation
Dendritic Spine Development
Bicellular Tight Junction Assembly
Cellular Response To Transforming Growth Factor Beta Stimulus
Execution Phase Of Apoptosis
Regulation Of Actin Filament Organization
Protein Localization To Cell-cell Junction
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
Polo-like kinase mediated events
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
PPARA activates gene expression
PPARA activates gene expression
Formation of the beta-catenin:TCF transactivating complex
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
HATs acetylate histones
Attenuation phase
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
B-WICH complex positively regulates rRNA expression
Activation of anterior HOX genes in hindbrain development during early embryogenesis
CD209 (DC-SIGN) signaling
Metalloprotease DUBs
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Methylation
PI5P Regulates TP53 Acetylation
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NGF-stimulated transcription
NGF-stimulated transcription
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
FOXO-mediated transcription of cell death genes
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
STAT3 nuclear events downstream of ALK signaling
Heme signaling
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Nuclear events mediated by NFE2L2
Formation of paraxial mesoderm
NFE2L2 regulating inflammation associated genes
NFE2L2 regulating anti-oxidant/detoxification enzymes
NFE2L2 regulates pentose phosphate pathway genes
NFE2L2 regulating tumorigenic genes
NFE2L2 regulating MDR associated enzymes
NFE2L2 regulating ER-stress associated genes
Regulation of NFE2L2 gene expression
Regulation of NFE2L2 gene expression
Zygotic genome activation (ZGA)
Evasion by RSV of host interferon responses
TGFBR3 expression
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Transcriptional and post-translational regulation of MITF-M expression and activity
Transcriptional and post-translational regulation of MITF-M expression and activity
Regulation of PD-L1(CD274) transcription
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Nef and signal transduction
Generation of second messenger molecules
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Regulation of activated PAK-2p34 by proteasome mediated degradation
Stimulation of the cell death response by PAK-2p34
FCERI mediated MAPK activation
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
Drugs
Fostamatinib
Diseases
Rubinstein-Taybi syndrome
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Crohn's disease (
22936669
)
General risk tolerance (MTAG) (
30643258
)
Neuroticism (
29255261
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Schizophrenia (
25056061
28991256
29483656
)
Type 2 diabetes (
30297969
)
Asthma (
31959851
)
Atrial fibrillation (
29892015
)
Eosinophil count (
32888494
27863252
)
Glucose homeostasis traits (
25524916
)
Lymphocyte count (
27863252
32888494
)
Malaria (
31844061
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
27863252
32888494
)
Neutrophil count (
32888494
)
Platelet count (
27863252
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Total ventricular volume (Alzheimer's disease interaction) (
21116278
)
White blood cell count (
27863252
32888494
)
Interacting Genes
382 interacting genes:
ABL1
ACSM5
ACTA2
AHR
AKT1
ALKBH4
ALX1
APEX1
AR
ARHGDIA
ARNT
ARSF
ASCL1
ASH2L
ATF4
ATF5
ATR
BAG6
BCAS2
BCL3
BCL6
BMAL1
BRCA1
BRMS1
C1R
CALCOCO1
CARM1
CCNB1
CCND1
CDC25A
CDK2
CDT1
CDX2
CEBPA
CEBPB
CEBPD
CFH
CHD4
CITED1
CITED2
CITED4
CLIC2
CLOCK
CNOT4
COPS2
COPS6
CREBBP
CRX
CTBP1
CTBP2
CTF1
CTNNB1
CXCL8
CXXC1
DAO
DBP
DDIT3
DDX24
DECR2
DEK
DTX1
DUX4
E2F1
E2F5
EEF1A1
EGR1
EID1
EID2
ELF3
ELK1
ELL
EMB
EPAS1
EPO
ESR1
ESR2
ETS1
ETS2
ETV1
ETV4
EZH2
FBXL5
FEN1
FHL2
FOSB
FOSL1
FOSL2
FOXO3
FOXP3
GAA
GABPA
GABPB1
GATA4
GATA5
GATA6
GCKR
GLUL
GOLGA2
GPBP1
GPS2
GRB2
GRIP1
GTF2B
H1-1
H1-3
H2AC20
H2AC21
H2AC4
H2AC8
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4C1
H4C14
H4C16
H4C7
H4C9
HAND2
HBP1
HDAC1
HDAC3
HDAC6
HEMGN
HERC1
HIF1A
HMGB1
HMGN1
HMGN2
HNF1A
HNRNPU
HNRNPUL1
HOXA10
HOXB1
HOXB2
HOXB3
HOXB4
HOXB6
HOXB7
HOXB9
HOXD10
HOXD4
HPS6
HSP90AA2P
ILF2
ILF3
IMMT
ING1
ING2
ING4
ING5
IRF1
IRF2
IRF3
IRF5
IRF7
ITIH3
JDP2
JMY
JUN
JUNB
JUND
KAT2A
KAT2B
KAT5
KCTD5
KDM2A
KLF1
KLF13
KLF2
KLF5
KPNA2
KRT18
LEF1
MAF
MAGED1
MAML1
MAP2K1
MAP3K5
MAPK1
MAPK8
MAPT
MAX
MCHR1
MCM2
MCM3
MCM3AP
MCM4
MCM5
MDC1
MDM2
MDM4
MEF2A
MEF2C
MEF2D
MELTF
MGMT
MITF
MLXIPL
MN1
MORF4L1
MPG
MRE11
MSH6
MSTO1
MTOR
MYB
MYBL2
MYC
MYOD1
N4BP2
NAP1L1
NAP1L4
NBN
NCOA1
NCOA2
NCOA3
NCOA6
NEDD1
NEDD4
NEIL2
NEUROD1
NFATC1
NFATC2
NFYA
NFYB
NOTCH1
NOXA1
NPAS2
NPM1
NR1H4
NR1I2
NR2F2
NR3C1
NR4A1
NUP98
NUPR1
OLIG2
ORC2
PAK2
PAX6
PAX8
PAXIP1
PCK2
PCNA
PDHX
PELP1
PIAS1
PIAS3
PIN1
PLAGL1
PLG
PLSCR1
PLSCR2
PML
POLB
POLD2
POLI
POU3F2
PPARA
PPARD
PPARG
PPP2R5C
PRG4
PRKCA
PRKCB
PRKCD
PRKDC
PRMT1
PROX1
PTMA
RACK1
RAD23A
RAD50
RAN
RB1
RBM14
RBX1
RECQL4
REL
RELA
RORA
RPL27
RPS6KA5
RPS6KB1
RPS6KB2
RUNX1
RUNX2
RUNX3
RUVBL2
SATB1
SAV1
SDC4
SELENOP
SENP3
SERTAD1
SET
SETD1A
SIK2
SIRT1
SIRT2
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD7
SNIP1
SNRPA
SNW1
SOX9
SP1
SP3
SPHK1
SPIB
SREBF1
SREBF2
SRY
SS18
SS18L1
STAT1
STAT2
STAT3
STAT5A
STAT5B
STAT6
SUB1
SUMO2
SUV39H1
TACC2
TADA3
TAF1B
TAL1
TCF12
TCF3
TCF4
TCF7L2
TDG
TERF2
TFAP2A
TGFB1I1
TGS1
THPO
TINAGL1
TNIP2
TP53
TP53BP1
TP63
TP73
TRAF2
TRERF1
TRIP4
TSG101
TWIST1
UBC
UBE2D1
UBE2I
UBQLN1
UBTF
USF2
VPS18
WDR59
WDR82
XRCC6
YWHAZ
YY1
ZBTB16
ZBTB17
ZBTB48
ZBTB49
ZBTB5
ZBTB7B
ZBTB8A
ZC3H12A
ZEB1
ZFPM2
ZNF106
ZNF148
ZNF76
ZRANB2
54 interacting genes:
ABI1
ABI2
ABI3
ABL1
APP
ARHGAP10
ARHGEF6
ARHGEF7
BRAF
CASP3
CDC42
CEBPA
DOCK2
DSCR9
DST
EIF4B
EIF4G1
EP300
FYN
GRB2
H4C6
HCK
LCK
LIMK1
LYN
MAPK1
MAPK3
MKNK1
MYC
MYL2
MYLK
NCK1
NPHP1
OGT
PACSIN3
PPM1A
RAC1
RAF1
RIOK3
RPS6
SH3GL2
SH3KBP1
SH3PXD2A
SH3RF1
SH3RF3
SNX33
SNX9
SORBS1
SORBS2
SORBS3
SRC
SYN1
VIM
YES1
Entrez ID
2033
5062
HPRD ID
04078
05428
Ensembl ID
ENSG00000100393
ENSG00000180370
Uniprot IDs
A0A669KB12
Q09472
Q7Z6C1
A8K5M4
Q13177
PDB IDs
1L3E
1P4Q
2K8F
2MH0
2MZD
3BIY
3I3J
3IO2
3P57
3T92
4BHW
4PZR
4PZS
4PZT
5BT3
5KJ2
5LKT
5LKU
5LKX
5LKZ
5LPK
5LPM
5NU5
5XZC
6DS6
6FGN
6FGS
6GYR
6GYT
6K4N
6PF1
6PGU
6V8B
6V8K
6V8N
6V90
7LJE
7QGS
7SS8
7SSK
7SZQ
7UGI
7VHY
7VHZ
7VI0
7W9V
7XEZ
7XFG
8E1D
8FVF
8GZC
8HAG
8HAH
8HAI
8HAJ
8HAK
9JEJ
9JUT
3PCS
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Nucleoplasm
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Activity
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Transcription Cis-regulatory Region Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Regulation Of Developmental Process
Transcription Regulator Complex
Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
DNA-binding Transcription Factor Binding
Chromatin Binding
RNA Polymerase II Transcription Regulator Complex
Chromatin Organization
Cellular Response To Stress
Regulation Of Cell Population Proliferation
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Cellular Component Organization
Cytosol
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Intracellular Signal Transduction
Regulation Of Vesicle-mediated Transport
Cytoskeleton Organization
Positive Regulation Of Cellular Component Organization
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Cytoplasm
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Enzyme-linked Receptor Protein Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of MAPK Cascade
Focal Adhesion
Protein Phosphorylation
Ephrin Receptor Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Organelle Organization
Regulation Of Protein Metabolic Process
Intracellular Signaling Cassette
Fc Receptor Signaling Pathway
Phosphorylation
Positive Regulation Of Cytoskeleton Organization
Signal Transduction
Anchoring Junction
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Organelle Organization
Cell Surface Receptor Signaling Pathway
Regulation Of Protein-containing Complex Assembly
Immune Response-activating Signaling Pathway
Actin Cytoskeleton Organization
Non-membrane Spanning Protein Tyrosine Kinase Activity
Endocytosis
Regulation Of Cell Activation
Regulation Of Transport
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Regulation Of Supramolecular Fiber Organization
Regulation Of Endocytosis
Regulation Of T Cell Activation
Ephrin Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Supramolecular Fiber Organization
Actin Filament-based Process
Protein Kinase Activity
Lamellipodium
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Tagcloud (Intersection)
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