CENPX and FANCM

Number of citations of the paper that reports this interaction (PubMedID 26625197)
67

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		CENPX	FANCM
Description		centromere protein X	FA complementation group M
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex
	Molecular Function	DNA Binding Double-stranded DNA Binding Protein Binding	Nucleotide Binding Four-way Junction DNA Binding Nucleic Acid Binding DNA Binding Chromatin Binding RNA Helicase Activity Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates DNA Repair DNA Damage Response Chromosome Segregation Replication Fork Processing Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair Cell Division Kinetochore Assembly	Resolution Of Meiotic Recombination Intermediates DNA Repair DNA Damage Response Replication Fork Processing Homologous Recombination Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Positive Regulation Of Protein Monoubiquitination
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere Fanconi Anemia Pathway PKR-mediated signaling	Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases			Fanconi anemia
GWAS			Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		8 interacting genes: CENPS FANCM LRRC45 NKX3-1 REL TP53 TRIM54 UBE2I	11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I
Entrez ID		201254	57697
HPRD ID		18121	13876
Ensembl ID		ENSG00000169689	ENSG00000187790
Uniprot IDs		A8MT69 J3QRS1	A0A8Q3WLG3 Q8IYD8
PDB IDs		4DRA 4DRB 4E44 4E45 4NDY 4NE1 4NE3 4NE5 4NE6 7R5S 7XHN 7XHO 7YWX	4BXO 4DAY 4DRB 4E45 4M6W
Enriched GO Terms of Interacting Partners?		FANCM-MHF Complex Fanconi Anaemia Nuclear Complex Resolution Of Meiotic Recombination Intermediates Chromatin Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Somitogenesis DNA Damage Response Segmentation Cellular Response To Xenobiotic Stimulus Positive Regulation Of Androgen Secretion MADS Box Domain Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition SUMO Conjugating Enzyme Activity Replication Fork Processing Interstrand Cross-link Repair Meiosis I Cell Cycle Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To Hypoxia Histone Deacetylase Binding Response To Stress Salivary Gland Development DNA Binding Dorsal Aorta Development Cytosol NF-kappaB Complex Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate DNA Repair PML Body Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Chromatin Binding RING-like Zinc Finger Domain Binding Chromosome Segregation SUMO Ligase Complex HLH Domain Binding Double-strand Break Repair Via Synthesis-dependent Strand Annealing Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Cellular Response To Decreased Oxygen Levels Positive Regulation Of Apoptotic Signaling Pathway	Resolution Of DNA Recombination Intermediates Resolution Of Meiotic Recombination Intermediates RecQ Family Helicase-topoisomerase III Complex FANCM-MHF Complex Response To Stress Cellular Response To Manganese Ion Cellular Response To Stress DNA Repair Meiosis I Cell Cycle Process Fanconi Anaemia Nuclear Complex Response To Manganese Ion Golgi-associated Vesicle Reproductive Process Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity DNA Metabolic Process DNA Damage Response Presynaptic Cytosol Cellular Response To Metal Ion Regulation Of Neuron Differentiation Clathrin Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Interstrand Cross-link Repair Replication Fork Processing Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Macromolecule Metabolic Process Double-strand Break Repair Regulation Of CAMP/PKA Signal Transduction DNA Recombination Modulation Of Excitatory Postsynaptic Potential Protein Sumoylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly SUMO Conjugating Enzyme Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Nucleoplasm Cytosol DNA Binding Endosome Acetylcholine Receptor Activator Activity Response To Metal Ion Positive Regulation Of Protein Metabolic Process
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