CENPX and LRRC45

		CENPX	LRRC45
Description		centromere protein X	leucine rich repeat containing 45
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Fanconi Anaemia Nuclear Complex FANCM-MHF Complex	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Ciliary Basal Body
	Molecular Function	DNA Binding Double-stranded DNA Binding Protein Binding	Protein Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates DNA Repair DNA Damage Response Chromosome Segregation Replication Fork Processing Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair Cell Division Kinetochore Assembly
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere Fanconi Anemia Pathway PKR-mediated signaling
Drugs
Diseases
GWAS			Neuroblastoma (pediatric) ( 32599975) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: CENPS FANCM LRRC45 NKX3-1 REL TP53 TRIM54 UBE2I	13 interacting genes: ALAS1 CCDC89 CENPX KXD1 MCC MID2 MYADML2 RBFOX3 SSX2 SSX2B SSX7 THAP11 ZDHHC17
Entrez ID		201254	201255
HPRD ID		18121	14476
Ensembl ID		ENSG00000169689	ENSG00000169683
Uniprot IDs		A8MT69 J3QRS1	Q96CN5
PDB IDs		4DRA 4DRB 4E44 4E45 4NDY 4NE1 4NE3 4NE5 4NE6 7R5S 7XHN 7XHO 7YWX
Enriched GO Terms of Interacting Partners?		FANCM-MHF Complex Fanconi Anaemia Nuclear Complex Resolution Of Meiotic Recombination Intermediates Chromatin Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Somitogenesis DNA Damage Response Segmentation Cellular Response To Xenobiotic Stimulus Positive Regulation Of Androgen Secretion MADS Box Domain Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition SUMO Conjugating Enzyme Activity Replication Fork Processing Interstrand Cross-link Repair Meiosis I Cell Cycle Process Positive Regulation Of Intracellular Signal Transduction Cellular Response To Hypoxia Histone Deacetylase Binding Response To Stress Salivary Gland Development DNA Binding Dorsal Aorta Development Cytosol NF-kappaB Complex Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate DNA Repair PML Body Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Chromatin Binding RING-like Zinc Finger Domain Binding Chromosome Segregation SUMO Ligase Complex HLH Domain Binding Double-strand Break Repair Via Synthesis-dependent Strand Annealing Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Cellular Response To Decreased Oxygen Levels Positive Regulation Of Apoptotic Signaling Pathway
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