MARK2 and PTPRD

Number of citations of the paper that reports this interaction (PubMedID 22305495)
32

Data Source:
BioGRID (pull down)

		MARK2	PTPRD
Description		microtubule affinity regulating kinase 2	protein tyrosine phosphatase receptor type D
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle	Plasma Membrane Membrane Presynaptic Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Cell Adhesion Molecule Binding
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly	Phosphate-containing Compound Metabolic Process Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Dendrite Morphogenesis Regulation Of Immune Response Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Presynaptic Membrane Assembly Presynapse Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion
Pathways			Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
Drugs		Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Anxiety and major depressive disorder ( 24047446) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bitter alcoholic beverage consumption ( 31046077) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Cardiac Troponin-T levels ( 31014085) Cardiorespiratory fitness (800m run time) ( 32572135) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) DHEAS levels ( 34748635) Diastolic blood pressure ( 30224653) Early age at menarche ( 29773799) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Epilepsy (remission after treatment) ( 23962720) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Femur bone mineral density x serum urate levels interaction ( 34046847) Gait rhythm ( 26219847) Glycine levels ( 31070104) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Intracranial aneurysm ( 29531279) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lean body mass ( 28552196) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 29773799 25231870) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Moderate-to-late spontaneous preterm birth ( 31194736) Modic changes ( 30808802) Mood instability ( 29187730) Morning person ( 30696823) Myopia (pathological) ( 23049088) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Non-response to antidepressants and depression ( 27622933) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 24821223) Obsessive-compulsive traits ( 33531474) Opioid use cessation ( 31936517) Palmitic acid (16:0) levels ( 23362303) Parkinson's disease progression (motor) ( 33111402) Partial epilepsies ( 20522523) Pelvic organ prolapse (moderate/severe) ( 26545240) Personality dimensions ( 23903073) Pit-and-Fissure caries ( 24556642) Plasma clusterin levels ( 26545630) Platelet aggregation ( 20526338) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Resistant hypertension ( 30237584) Resting-state electroencephalogram vigilance ( 29703947) Restless legs syndrome ( 18660810 33239738 29029846 21779176) Short-term memory (digit-span task) ( 30741946) Smoking initiation ( 33082346) spontaneous preterm birth x maternal stress interaction (1df) ( 32726798) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure ( 30224653 27841878) Temperament ( 22832960) Third ventricle volume ( 31530798) Triglyceride levels ( 34074324) Triglyceride levels in HIV infection ( 33109212) Type 2 diabetes ( 21647700 20174558) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		41 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 FLRT1 GAB1 GSK3B HDAC7 INCENP ISOC1 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L NUAK1 NXF1 OSBP PAK5 PARD3B PARD6A PINK1 PKD1 PLAAT3 PPP2R5B PRKCE PTPRD RAB11FIP2 RNF41 RPA2 RPS6KB1 SCGB1A1 SMURF1 STK11 STK3 YWHAB YWHAZ	43 interacting genes: ABLIM1 AURKA BMX CSNK1D CSNK1E DDX17 DDX54 EPHA8 ERG GPC4 GRIK1 HUNK IL1RAP IRS1 KCNJ6 MARK2 MATK MTNR1A MTNR1B MTSS1 NEK1 NEK2 NEK6 OMG PAK6 PLK1 PPFIA1 PPFIA2 PPFIA3 PTPRA PTPRE PTPRF PTPRS RCAN1 RSPH1 SCEL SLAIN2 SLITRK1 SMTNL2 TBK1 TMEM132D TRAFD1 TSSK2
Entrez ID		2011	5789
HPRD ID		02753	03358
Ensembl ID		ENSG00000072518	ENSG00000153707
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	P23468 Q2HXI4 Q3KPI9 Q59H90
PDB IDs		3IEC 5EAK 5KZ7 5KZ8 8TXY	1X5Z 2DLH 2YD6 2YD7 4RCA 5WY8 5XNP 6X3A
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding	Protein Kinase Activity Protein Phosphorylation Phosphorylation Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Synaptic Membrane Adhesion ATP Binding Phosphate-containing Compound Metabolic Process Nucleotide Binding Protein Autophosphorylation Protein Modification Process Microtubule Cytoskeleton Organization Signal Transduction Cytoskeleton Organization Centrosome Separation Peptidyl-serine Phosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Transferase Activity Protein Localization To Centrosome Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Melatonin Receptor Activity Spindle Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Projection Organization Spindle Assembly Mitotic Spindle Organization Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Microtubule-based Process Presynaptic Active Zone Spindle Microtubule Cytoskeleton Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Proteasomal Protein Catabolic Process Cell Surface Receptor Signaling Pathway Protein Localization To Cytoskeleton Plasma Membrane Bounded Cell Projection Organization Protein Tyrosine Kinase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Nuclear Membrane Disassembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Phosphoprotein Phosphatase Activity Synapse Organization Postsynaptic Density Glutamatergic Synapse
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?