MARK2 and FLRT1

		MARK2	FLRT1
Description		microtubule affinity regulating kinase 2	fibronectin leucine rich transmembrane protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Matrix Cytoplasmic Vesicle Neuronal Cell Body Membrane Cell Projection Neuron Projection Neuron Projection Terminus Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Fibroblast Growth Factor Receptor Binding Protein-macromolecule Adaptor Activity
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly	Cell Adhesion Fibroblast Growth Factor Receptor Signaling Pathway Dendrite Development Positive Regulation Of Synapse Assembly Neuron Projection Extension
Pathways			Downstream signaling of activated FGFR1
Drugs		Fostamatinib
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)	A body shape index ( 34021172) Fruit consumption ( 32066663) Inflammatory bowel disease ( 23128233) Triglyceride levels ( 33339817) Urate levels ( 31985003) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		41 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 FLRT1 GAB1 GSK3B HDAC7 INCENP ISOC1 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L NUAK1 NXF1 OSBP PAK5 PARD3B PARD6A PINK1 PKD1 PLAAT3 PPP2R5B PRKCE PTPRD RAB11FIP2 RNF41 RPA2 RPS6KB1 SCGB1A1 SMURF1 STK11 STK3 YWHAB YWHAZ	2 interacting genes: GPR35 MARK2
Entrez ID		2011	23769
HPRD ID		02753	05311
Ensembl ID		ENSG00000072518	ENSG00000126500
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	Q9NZU1
PDB IDs		3IEC 5EAK 5KZ7 5KZ8 8TXY
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding	Microtubule Bundle Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Tau-protein Kinase Activity Regulation Of Inclusion Body Assembly Chemokine Receptor Activity Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Transporter Activity Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Kinase Activator Activity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tau Protein Binding Mitochondrion Localization Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transport Axon Development Lateral Plasma Membrane Autophagy Of Mitochondrion Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Transmembrane Transporter Activity Chemokine-mediated Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transporter Activity Actin Filament Establishment Of Cell Polarity Negative Regulation Of Monoatomic Ion Transport Cell Surface Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport
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