MUC20 and ELOVL3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MUC20	ELOVL3
Description		mucin 20, cell surface associated	ELOVL fatty acid elongase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Identical Protein Binding	Protein Binding Fatty Acid Elongase Activity Transferase Activity
	Biological Process	Hepatocyte Growth Factor Receptor Signaling Pathway	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Sphingolipid Biosynthetic Process Fatty Acid Elongation Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongation, Polyunsaturated Fatty Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family MET activates RAS signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Lung disease severity in cystic fibrosis ( 26417704)	Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Refractive error ( 32231278) Smoking initiation ( 33082346) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: ALDOB ELOVL3 MET	1 interacting genes: MUC20
Entrez ID		200958	83401
HPRD ID		17615	16858
Ensembl ID		ENSG00000176945	ENSG00000119915
Uniprot IDs		A0A0G2JN31 A0A0G2JR26 A0A0G2JSE2 Q8N307	Q9HB03
PDB IDs
Enriched GO Terms of Interacting Partners?		Vacuolar Proton-transporting V-type ATPase Complex Assembly Fructose Catabolic Process Regulation Of NADP Metabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Fructose-bisphosphate Aldolase Activity Fructose Binding Negative Regulation Of Pentose-phosphate Shunt Fructose 1,6-bisphosphate Metabolic Process Fructose-1-phosphate Aldolase Activity Regulation Of Pentose-phosphate Shunt Proton-transporting V-type ATPase Complex Assembly Hepatocyte Growth Factor Receptor Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Hepatocyte Growth Factor Receptor Signaling Pathway Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Fatty Acid Elongation, Saturated Fatty Acid Fatty Acid Elongation, Monounsaturated Fatty Acid Small Molecule Biosynthetic Process Fructose Metabolic Process Glyceraldehyde-3-phosphate Metabolic Process Purine-containing Compound Metabolic Process Monocarboxylic Acid Metabolic Process Positive Regulation Of Endothelial Cell Chemotaxis Semaphorin Receptor Activity Endothelial Cell Morphogenesis Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Alpha-linolenic Acid Metabolic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Linoleic Acid Metabolic Process Negative Regulation Of Rho Protein Signal Transduction Molecular Function Activator Activity Long-chain Fatty-acyl-CoA Metabolic Process Pancreas Development Carboxylic Acid Metabolic Process Fatty-acyl-CoA Biosynthetic Process Organic Acid Metabolic Process Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Microtubule Polymerization Epithelial Cell Morphogenesis Very Long-chain Fatty Acid Metabolic Process Establishment Of Skin Barrier Negative Regulation Of Actin Filament Bundle Assembly Skin Epidermis Development Unsaturated Fatty Acid Biosynthetic Process	Hepatocyte Growth Factor Receptor Signaling Pathway Microvillus Membrane Basal Plasma Membrane Golgi Lumen
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