EML1 and ISG20L2

Number of citations of the paper that reports this interaction (PubMedID 19060904)
32

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		EML1	ISG20L2
Description		EMAP like 1	interferon stimulated exonuclease gene 20 like 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle Mitotic Spindle Pole Mitotic Spindle Midzone	Nucleus Nucleolus
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Tubulin Binding	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Protein Binding Hydrolase Activity
	Biological Process	Microtubule Cytoskeleton Organization Hematopoietic Progenitor Cell Differentiation Mitotic Spindle Organization Neuroblast Proliferation Brain Development	DNA Metabolic Process RNA Processing Ribosome Biogenesis
Pathways			Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Depression in smokers ( 30219690) Pulse pressure ( 27841878) Scalp hair shape ( 26926045) Visceral fat ( 30942860)	Plateletcrit ( 27863252)
Interacting Genes		9 interacting genes: CKB GRID1 GRID2 GRIN2A ISG20L2 MTDH PTEN TUBA1A UBE3A	2 interacting genes: EML1 HSPB1
Entrez ID		2009	81875
HPRD ID		03613	07788
Ensembl ID		ENSG00000066629	ENSG00000143319
Uniprot IDs		O00423	Q9H9L3
PDB IDs		4CI8	7YW5
Enriched GO Terms of Interacting Partners?		Dendritic Spine Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Synaptic Signaling Via Neuropeptide Forebrain Morphogenesis Chemical Synaptic Transmission Trans-synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Synaptic Signaling Prepulse Inhibition Startle Response Synapse Regulation Of Membrane Potential Monoatomic Ion Channel Activity Dentate Gyrus Development AMPA Glutamate Receptor Complex Glutamatergic Synapse Positive Regulation Of Excitatory Postsynaptic Potential Cell-cell Signaling Signaling Postsynaptic Membrane Cell Communication Synapse Organization Modulation Of Excitatory Postsynaptic Potential Signaling Receptor Activity Learning Or Memory Social Behavior Visual Learning Regulation Of Synapse Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Excitatory Postsynaptic Potential Visual Behavior Cognition Negative Regulation Of Synaptic Vesicle Clustering Sperm Entry Positive Regulation Of Golgi Lumen Acidification Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels PDZ Domain Binding Futile Creatine Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration	Negative Regulation Of Protein Kinase C Signaling Mitotic Spindle Midzone Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Contractile Muscle Fiber Microtubule-based Process Neuroblast Proliferation Cytoskeleton Microtubule Associated Complex Tubulin Binding Mitotic Spindle Pole Protein Localization To Synapse Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Protein Folding Chaperone Protein Kinase C Binding Platelet Aggregation Axon Cytoplasm Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Interleukin-1 Beta Production Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Axonal Transport Anterograde Axonal Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cornified Envelope Protein Refolding Proteasome Complex Homotypic Cell-cell Adhesion Positive Regulation Of Interleukin-1 Production
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