CC2D1B and KLHL40

Number of citations of the paper that reports this interaction (PubMedID 24960163)
62

Data Source:
BioGRID (two hybrid)

		CC2D1B	KLHL40
Description		coiled-coil and C2 domain containing 1B	kelch like family member 40
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytosol Endosome Membrane	Cytoplasm Cul3-RING Ubiquitin Ligase Complex A Band I Band
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Fiber Development Skeletal Muscle Fiber Differentiation
Pathways		Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: KLHL40 LINC00839 MDFI RNF10 SPP1	13 interacting genes: AHNAK CC2D1B FBXL9P FSD2 LMOD3 REL SAR1A SAXO1 SPMIP4 TASOR2 VDAC1 ZBED1 ZNF451
Entrez ID		200014	131377
HPRD ID		12393	11058
Ensembl ID		ENSG00000154222	ENSG00000157119
Uniprot IDs		Q5T0F9	A8K5H9 Q2TBA0
PDB IDs			4ASC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Negative Regulation Of Nervous System Development Negative Regulation Of Neurogenesis Regulation Of Estradiol Secretion Dorsal/ventral Axis Specification Trophoblast Giant Cell Differentiation Positive Regulation Of Bone Resorption Response To Macrophage Colony-stimulating Factor Hormone Catabolic Process Androgen Catabolic Process Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Cellular Response To Testosterone Stimulus Regulation Of Neurogenesis Negative Regulation Of Neuron Projection Regeneration Negative Regulation Of Cell Development Response To 2,3,7,8-tetrachlorodibenzodioxine Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Skeletal Muscle Fiber Differentiation A Band	SUMO Ligase Activity
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