ELAVL1 and PAIP2

Number of citations of the paper that reports this interaction (PubMedID 15175342)
0

Data Source:
HPRD (in vitro, in vivo)

		ELAVL1	PAIP2
Description		ELAV like RNA binding protein 1	poly(A) binding protein interacting protein 2
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Sarcoplasm Cytoplasmic Vesicle Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity LncRNA Binding	MRNA Regulatory Element Binding Translation Repressor Activity MRNA Binding Protein Binding Translation Repressor Activity
	Biological Process	LncRNA-mediated Post-transcriptional Gene Silencing Protein Import Into Nucleus Cell Population Proliferation Response To Glucose Positive Regulation Of Autophagy Post-transcriptional Gene Silencing Positive Regulation Of Superoxide Anion Generation Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Autophagosome Size MRNA Stabilization Protein Homooligomerization Negative Regulation Of MiRNA-mediated Gene Silencing MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance	Translation Regulation Of Translation Spermatogenesis Memory Negative Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Long-term Synaptic Potentiation
Pathways		HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS			Body mass index ( 26426971) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Malaria ( 31844061)
Interacting Genes		45 interacting genes: AKT1 ANP32A ANP32B APOE C12orf75 CARM1 CEBPA CELF2 CHEK2 CTNNB1 DNM2 ERG FAF2 GJB3 HNRNPK HOTAIR IL6 IL7R KPNA1 KPNB1 LINC00460 LINC00632 MIRLET7B MIRLET7I NEIL3 NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SHANK3 SREK1 TNPO1 TNPO2 TRIM21 VCP VEGFA	6 interacting genes: APP ELAVL1 PABPC1 RPL11 TRIM54 UBR5
Entrez ID		1994	51247
HPRD ID		16025	05726
Ensembl ID		ENSG00000066044	ENSG00000120727
Uniprot IDs		Q15717	Q49AE6 Q9BPZ3
PDB IDs		3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3	1JGN 3KUS 3KUT
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Enzyme Binding Regulation Of Primary Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Import Signal Receptor Activity Regulation Of Signal Transduction Regulation Of Platelet Activation Nuclear Localization Sequence Binding Regulation Of Macromolecule Metabolic Process Stress Granule Disassembly Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Blood Coagulation Positive Regulation Of Catabolic Process Intracellular Signaling Cassette Regulation Of Fat Cell Differentiation Regulation Of Hemostasis Regulation Of Wound Healing Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Response To Oxidative Stress Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Response To Wounding Urokinase Plasminogen Activator Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Differentiation Diacylglycerol-dependent Serine/threonine Kinase Activity	Regulation Of Superoxide Anion Generation Positive Regulation Of Gene Expression Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Translation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Autophagosome Size Negative Regulation Of MRNA Catabolic Process RNA Stabilization MRNA Stabilization Negative Regulation Of Catabolic Process Ribonucleoprotein Complex Positive Regulation Of Macromolecule Biosynthetic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Macromolecule Metabolic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of RNA Catabolic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Positive Regulation Of MRNA Metabolic Process RNA Binding Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System Heterochromatin Boundary Formation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response
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