ELANE and F2R

Number of citations of the paper that reports this interaction (PubMedID 10978167)
0

Data Source:
HPRD (in vitro)

		ELANE	F2R
Description		elastase, neutrophil expressed	coagulation factor II thrombin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome	Extracellular Region Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Caveola Cell Surface Membrane Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Hemostasis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Anatomical Structure Morphogenesis Glutamate Secretion Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Dendritic Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Cell-cell Junction Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Synaptic Plasticity Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Platelet Dense Granule Organization Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Negative Regulation Of Renin Secretion Into Blood Stream
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes	Common Pathway of Fibrin Clot Formation Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid	Streptokinase SR-123781A Vorapaxar Thrombin
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Blood protein levels ( 30072576)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Mean platelet volume ( 22139419) Platelet count ( 22139419) Platelet distribution width ( 27863252)
Interacting Genes		31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1	20 interacting genes: ATP13A2 CAPN1 CHRD CTSG CXCL14 ELANE F2 F2RL1 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNCA SNX1
Entrez ID		1991	2149
HPRD ID		00554	01763
Ensembl ID		ENSG00000197561	ENSG00000181104
Uniprot IDs		P08246	P25116
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU	1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7 8XOR 8XOS
Enriched GO Terms of Interacting Partners?		Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Biological Process Involved In Interaction With Symbiont Neutrophil-mediated Killing Of Bacterium Serine-type Peptidase Activity Serine-type Endopeptidase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Locomotion D5 Dopamine Receptor Binding Extracellular Exosome Biogenesis Regulation Of Vesicle-mediated Transport Neutrophil Mediated Immunity Regulation Of Exocytosis Positive Regulation Of Exocytosis Leukocyte Migration Killing By Host Of Symbiont Cells Coagulation Blood Coagulation Regulation Of Cell Migration Protease Binding Hemostasis Extracellular Vesicle Biogenesis Peptidase Activity Regulation Of Cell Motility Killing Of Cells Of Another Organism Neutrophil-mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Regulation Of Body Fluid Levels Regulation Of Reactive Oxygen Species Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion By Cell Rho-activating G Protein-coupled Receptor Signaling Pathway Extracellular Matrix Disassembly Positive Regulation Of Secretion GTPase Activity Regulation Of Catalytic Activity Antimicrobial Humoral Response Extracellular Exosome Regulation Of Secretion By Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Chaperone-mediated Autophagy Extracellular Region Regulation Of Biological Quality Regulation Of Cell Population Proliferation Cell Migration GTP Binding Positive Regulation Of Cell Population Proliferation
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