EIF4B and EIF4E

Number of citations of the paper that reports this interaction (PubMedID 2016328)
0

Data Source:
HPRD (in vitro)

		EIF4B	EIF4E
Description		eukaryotic translation initiation factor 4B	eukaryotic translation initiation factor 4E
Image
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Nuclear Body Nuclear Speck Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding RNA Strand Annealing Activity RNA Strand-exchange Activity Ribosomal Small Subunit Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding Translation Initiation Factor Activity Protein Binding Enzyme Binding Eukaryotic Initiation Factor 4G Binding MRNA Cap Binding DNA-binding Transcription Factor Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Assembly	G1/S Transition Of Mitotic Cell Cycle Behavioral Fear Response MRNA Export From Nucleus Translation Translational Initiation Regulation Of Translation Negative Regulation Of Autophagy Negative Regulation Of Translation Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Mitotic Cell Cycle MRNA Transport Nuclear Export Cellular Response To Dexamethasone Stimulus Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs			7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Prostate cancer ( 21743057)	Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol dependence ( 33290381) Daytime sleep phenotypes ( 27126917) HDL cholesterol levels ( 32203549) Mean arterial pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Menopause (age at onset) ( 29773799) Sensation seeking ( 30718321)
Interacting Genes		21 interacting genes: ACD CASP3 CEBPA CSNK2A1 EIF3A EIF4E IPO13 LAMTOR5 LINC01554 PABPC1 PAK2 POT1 PRKN RHOU RPS6KB1 SFN SMAD3 SRPK2 TERF1 TINF2 USP11	39 interacting genes: ACVRL1 APP BIRC2 BRWD1 CD83 CEBPA CPEB1 CYFIP1 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 EN2 GEMIN5 HOXA9 IPO8 KANK2 LRPPRC MAPKAPK5 MKNK1 MKNK2 OTX2 PML PRDM4 PRKCA PRKCB PRKCG PTEN RNMT TDO2 TLX1 TRIM27 UBXN11 XPO1
Entrez ID		1975	1977
HPRD ID		04892	00591
Ensembl ID		ENSG00000063046	ENSG00000151247
Uniprot IDs		B4DRM3 E7EX17 P23588 Q7Z5Y0	D6RBW1 P06730 Q32Q75 X5D7E3
PDB IDs		1WI8 2J76 6FEC	1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML 7D6Y 7D8B 7EZW 7F07 7MEU 7XTP 8QM4 8QM5 8QM6 8QM7 8QM8 8QM9 8SX4 9DON
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Response To Glucocorticoid Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Response To Corticosteroid Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Negative Regulation Of Biosynthetic Process Execution Phase Of Apoptosis RNA-templated DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Steroid Hormone Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Macromolecule Metabolic Process Positive Regulation Of Chromosome Organization Organelle Organization Regulation Of Telomere Maintenance Positive Regulation Of Macromolecule Metabolic Process Telomere Organization Intracellular Signal Transduction Regulation Of Cell Cycle Response To Dexamethasone Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization Positive Regulation Of Metabolic Process Cellular Component Assembly Regulation Of Macromolecule Metabolic Process DEAD/H-box RNA Helicase Binding Regulation Of Macromolecule Biosynthetic Process Nucleus	Regulation Of Translation Post-transcriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Eukaryotic Initiation Factor 4E Binding Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Translational Initiation Negative Regulation Of Translation Negative Regulation Of Metabolic Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Translation Repressor Activity Negative Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Translation Factor Activity, RNA Binding Positive Regulation Of Biosynthetic Process Calcium-dependent Protein Serine/threonine Kinase Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Translation Negative Regulation Of Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Translational Initiation Positive Regulation Of RNA Metabolic Process Protein Metabolic Process Translation Initiation Factor Activity PML Body Histone H3T6 Kinase Activity Cognition Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Calcium/calmodulin-dependent Protein Kinase Activity Regulation Of Cell Cycle Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Protein Kinase C Signaling Learning Or Memory Translational Initiation
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