MEGF8 and SYT5

		MEGF8	SYT5
Description		multiple EGF like domains 8	synaptotagmin 5
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Membrane Extracellular Exosome	Endosome Plasma Membrane Membrane Axon Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Exocytic Vesicle Neuronal Dense Core Vesicle Membrane Proximal Neuron Projection
	Molecular Function	Calcium Ion Binding Protein Binding	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding Metal Ion Binding Protein Heterodimerization Activity Calcium Ion Sensor Activity
	Biological Process	Morphogenesis Of An Epithelium Embryonic Heart Tube Morphogenesis Smoothened Signaling Pathway Determination Of Left/right Symmetry Heart Development Regulation Of Gene Expression Protein Ubiquitination Embryonic Limb Morphogenesis BMP Signaling Pathway Limb Morphogenesis Aorta Development Cell Migration Involved In Gastrulation Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Embryonic Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Epiboly Involved In Gastrulation With Mouth Forming Second Limb Development Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Coronary Vasculature Development Determination Of Heart Left/right Asymmetry Pharyngeal Arch Artery Morphogenesis Protein-containing Complex Assembly Determination Of Digestive Tract Left/right Asymmetry Craniofacial Suture Morphogenesis Fasciculation Of Sensory Neuron Axon Embryonic Brain Development	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Synaptic Vesicle Exocytosis
Pathways			Regulation of insulin secretion
Drugs
Diseases
GWAS			Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		8 interacting genes: ATN1 CACNA1A CCNE1 GFI1B HOXA1 HPN SYT5 URI1	8 interacting genes: DNAJC5 HTR6 MEGF8 NRXN1 POLR2E RAB1A SHANK3 SYT3
Entrez ID		1954	6861
HPRD ID		10370	02870
Ensembl ID		ENSG00000105429	ENSG00000129990
Uniprot IDs		Q7Z7M0	O00445 Q4FD32
PDB IDs			5H4Y 5H4Z
Enriched GO Terms of Interacting Partners?		Cochlea Morphogenesis Syntaxin Binding Neuronal Cell Body Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Cyclin E1-CDK2 Complex Negative Regulation Of RNA Biosynthetic Process Nuclear Matrix Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Positive Regulation Of Thyroid Hormone Generation Basement Membrane Disassembly Pilomotor Reflex Regulation Of Thyroid Hormone Generation Serine-type Exopeptidase Activity Neuronal Dense Core Vesicle Membrane Proximal Neuron Projection Negative Regulation Of Phosphatase Activity Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of G1/S Transition Of Mitotic Cell Cycle	Guanylate Kinase-associated Protein Clustering NMDA Glutamate Receptor Clustering Vocal Learning Observational Learning Neurotransmitter-gated Ion Channel Clustering Auditory Behavior Mechanosensory Behavior Vocalization Behavior Signal Release Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Nervous System Development Transport Vesicle Membrane Receptor Clustering Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Epiboly Involved In Gastrulation With Mouth Forming Second Plasma Membrane Bounded Cell Projection Organization Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Social Behavior Synapse Regulation Of Synaptic Transmission, Glutamatergic Neuromuscular Junction Secretion By Cell Regulation Of Nervous System Development Cell Projection Organization Melanosome Protein Complex Involved In Cell-cell Adhesion Synapse Assembly Positive Regulation Of Cellular Component Organization Neuron Projection Development Neuromuscular Process Fasciculation Of Sensory Neuron Axon Secretion Vesicle Localization Regulation Of Nervous System Process Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Central Nervous System Neuron Differentiation Negative Regulation Of Filopodium Assembly Synaptic Receptor Adaptor Activity Positive Regulation Of Developmental Process
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