EFNB2 and RGS3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		EFNB2	RGS3
Description		ephrin B2	regulator of G protein signaling 3
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GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Focal Adhesion Membrane Dendrite Presynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Ephrin Receptor Binding Receptor Ligand Activity	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Angiogenesis Lymph Vessel Development Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Nervous System Development Axon Guidance Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Neuron Projection Development Cell Differentiation T Cell Costimulation Adherens Junction Organization Keratinocyte Proliferation Symbiont Entry Into Host Cell Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Venous Blood Vessel Morphogenesis Regulation Of Chemotaxis Cellular Response To Lipopolysaccharide Nephric Duct Morphogenesis Presynapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Aorta Morphogenesis Positive Regulation Of Cardiac Muscle Cell Differentiation	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		BMI x environmental factors (excluding physical activity) interaction ( 33654129) BMI x environmental factors (including physical activity) interaction ( 33654129) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Metabolite levels ( 23823483) Pediatric autoimmune diseases ( 26301688) Subcutaneous adipose tissue ( 26480920)	Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		23 interacting genes: ANKRD46 DLG4 EPHA3 EPHA4 EPHB1 EPHB2 EPHB4 EPHB6 GRIP1 GRM1 GRM5 HOMER1 NCK2 PDZRN3 PECAM1 PICK1 PSEN1 PTPN13 RELN RGS3 RHBDL2 SDCBP SRC	25 interacting genes: ACD APP CDK6 CNKSR2 CYSRT1 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		1948	5998
HPRD ID		02754	03720
Ensembl ID		ENSG00000125266	ENSG00000138835
Uniprot IDs		P52799	A0A087WUY2 A0A8Q3WKG2 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3
PDB IDs		2HLE 2I85 2VSK 2VSM 2WO2 3GXU 4UF7 6P7Y 6PDL	2F5Y 2OJ4 3FBK
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Ephrin Receptor Activity Dendrite Transmembrane-ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Cell Surface Receptor Signaling Pathway Plasma Membrane Neuron Projection Organization Positive Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Neuron Projection Cell Recognition Protein Tyrosine Kinase Activity Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Postsynaptic Density Regulation Of Synaptic Transmission, Glutamatergic Cell Projection Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendritic Spine Organization Cell Migration Regulation Of Synapse Organization Regulation Of Cell Projection Organization Signal Transduction Synapse Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Cell Communication Postsynapse Organization Glutamatergic Synapse Regulation Of Signaling Neuron Projection Guidance Cell Motility Axon Guidance Postsynaptic Membrane Regulation Of Signal Transduction Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Regulation Of Cell Morphogenesis Positive Regulation Of Signaling Cell Adhesion Dendritic Spine Development Regulation Of Postsynapse Organization Regulation Of Nervous System Development G Protein-coupled Glutamate Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Response To Amyloid-beta	Phosphoserine Residue Binding Enzyme Binding G Protein-coupled Receptor Binding Ephrin Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Developmental Process Protein Domain Specific Binding Regulation Of Spontaneous Synaptic Transmission Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Membrane Potential Ligand-gated Ion Channel Signaling Pathway Protein Sequestering Activity Signal Transduction Regulation Of Transport Protein Kinase Binding Negative Regulation Of Protein Localization To Nucleus Transmembrane Transporter Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Monoatomic Ion Transmembrane Transport Peptidase Activator Activity System Development Cellular Response To Manganese Ion Extracellular Exosome Ubiquitin Protein Ligase Binding Regulation Of Establishment Of Protein Localization Glutamatergic Synapse Regulation Of MiRNA Transcription Response To Manganese Ion Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Targeting Regulation Of Protein Localization Negative Regulation Of Protein Localization Response To Lead Ion Negative Regulation Of RNA Biosynthetic Process Regulation Of Monoatomic Ion Transport Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Catecholamine Stimulus Regulation Of Protein Transport Regulation Of Neurotransmitter Uptake Response To Catecholamine Focal Adhesion Guanyl Nucleotide Binding Startle Response Negative Regulation Of Transport Regulation Of Innate Immune Response Positive Regulation Of Protein Transport Melanosome Negative Regulation Of Macromolecule Metabolic Process G-protein Beta/gamma-subunit Complex Binding
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