EFNA3 and PRSS23

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EFNA3	PRSS23
Description		ephrin A3	serine protease 23
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Side Of Membrane	Extracellular Region Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Cell-cell Signaling Axon Guidance Negative Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Amyloid Precursor Protein Catabolic Process	Proteolysis
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Optic disc size ( 31809533) Prostate cancer ( 23535732) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin excretion ( 30220432)	Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 28869591 30598549) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		12 interacting genes: CD48 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 KRTAP1-1 KRTAP10-3 LCE2C MEOX2 NOTCH2NLA PRSS23	27 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SEC11C SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4 UBC
Entrez ID		1944	11098
HPRD ID		03225	07149
Ensembl ID		ENSG00000143590	ENSG00000150687
Uniprot IDs		P52797	O95084
PDB IDs
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway Transmembrane-ephrin Receptor Activity Protein Tyrosine Kinase Activity Fasciculation Of Motor Neuron Axon Fasciculation Of Sensory Neuron Axon Regulation Of GTPase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Guidance Axon Guidance Nephric Duct Morphogenesis Protein Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Axonal Fasciculation Neuron Projection Fasciculation Ephrin Receptor Binding Dendrite Neuron Projection Development Growth Factor Binding Regulation Of Catalytic Activity Neuron Recognition Notochord Cell Development DH Domain Binding Regulation Of Cell Junction Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Projection Organization Positive Regulation Of Protein Localization To Plasma Membrane Tube Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Morphogenesis Of An Epithelium Axial Mesoderm Formation Neuromuscular Junction Positive Regulation Of Protein Localization To Membrane ATP Binding Regulation Of Cell Adhesion Keratin Filament Negative Regulation Of Lymphangiogenesis Notochord Formation Schaffer Collateral - CA1 Synapse Plasma Membrane Bounded Cell Projection Organization Postsynaptic Density Membrane Tissue Morphogenesis Epithelial Tube Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Blood Vessel Endothelial Cell Migration
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