ECH1 and HTT

Number of citations of the paper that reports this interaction (PubMedID 15383276)
0

Data Source:
BioGRID (pull down, two hybrid)

		ECH1	HTT
Description		enoyl-CoA hydratase 1	huntingtin
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Centriole Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Catalytic Activity Protein Binding Isomerase Activity Delta(3,5)-delta(2,4)-dienoyl-CoA Isomerase Activity	P53 Binding Phosphoprotein Phosphatase Activity Protein Binding Profilin Binding Kinase Binding Heat Shock Protein Binding Dynactin Binding Identical Protein Binding Transmembrane Transporter Binding Dynein Intermediate Chain Binding Beta-tubulin Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation	Establishment Of Mitotic Spindle Orientation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Apoptotic Process Microtubule-based Process Golgi Organization Central Nervous System Development Regulation Of Signal Transduction Neurogenesis Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Destabilization Vocal Learning Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Cilium Assembly Vesicle Transport Along Microtubule Synaptic Vesicle Transport Positive Regulation Of Mitophagy Positive Regulation Of Lipophagy Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Peroxisomal protein import Peroxisomal protein import Mitochondrial protein degradation	Regulation of MECP2 expression and activity
Drugs			Copper
Diseases			Huntington's disease (HD)
GWAS		Blood protein levels ( 30072576) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)	Age at first birth ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alcohol consumption ( 31358974) Estimated glomerular filtration rate ( 31152163) Frailty index ( 34431594) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean platelet volume ( 32888494) Monobrow ( 27182965) Myocardial infarction ( 33532862) Neutrophil count ( 32888494) Parental lifespan ( 30642433) Platelet count ( 32888494) Serum sulfate level ( 27412988) Tuberculosis ( 29036319) Type 2 diabetes ( 30297969) Walking pace ( 33128006) White blood cell count ( 32888494) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		13 interacting genes: APP CSTF2 EEF1D EEF1G FAM9B FXR1 FXR2 HTT PAFAH1B3 SERPINB9 STAT3 TIMP1 TLR10	112 interacting genes: AKT1 AMFR AP2A2 BDKRB1 CASP1 CASP3 CASP6 CBS CEP126 CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ELP1 ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 H2AP H3C10 HAP1 HEYL HIP1 HIP1R HOXC11 HOXC4 HSP90AA1 HSPA8 HYPK IFT20 IFT57 IKBKB ING5 KAT2B MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUP58 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 PSME4 RASA1 REST RHEB RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655
Entrez ID		1891	3064
HPRD ID		02825	00883
Ensembl ID		ENSG00000104823	ENSG00000197386
Uniprot IDs		A0A384MR44 Q13011	P42858
PDB IDs		2VRE 8SK6	2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV 6EZ8 6N8C 6RMH 6X9O 6YEJ 7DXJ 7DXK 8R2O 8SAH 8VLX 8W15
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Endopeptidase Activity Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Peptidase Inhibitor Activity Translation Elongation Factor Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Positive Regulation Of MRNA Catabolic Process Translation Regulator Activity Protein Heterodimerization Activity Protein Homodimerization Activity Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of MRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Regulation Of Post-transcriptional Gene Silencing Regulation Of Defense Response Regulation Of Tumor Necrosis Factor Production Modulation Of Chemical Synaptic Transmission Positive Regulation Of ATP Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of MRNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Cellular Response To Nerve Growth Factor Stimulus Regulation Of RNA Stability Response To Nerve Growth Factor Amyloid-beta Complex Presynapse Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Calcium-mediated Signaling MRNA Binding Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Interleukin-1 Beta Production Translational Elongation Regulation Of Carbohydrate Catabolic Process Platelet Alpha Granule Lumen Identical Protein Binding Heat Shock Protein Binding Regulation Of Multicellular Organism Growth	Protein Binding Cellular Response To Stress Nucleoplasm Nucleus Identical Protein Binding Positive Regulation Of Cellular Component Biogenesis Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Cellular Component Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Innate Immune Response Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction Protein Modification Process Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Positive Regulation Of Organelle Organization Interleukin-18-mediated Signaling Pathway Regulation Of Defense Response Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Post-translational Protein Modification Transcription Coregulator Activity Regulation Of Cellular Response To Stress Protein-containing Complex Positive Regulation Of Metabolic Process
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