E2F4 and CHMP2A

Number of citations of the paper that reports this interaction (PubMedID 35253629)
75

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		E2F4	CHMP2A
Description		E2F transcription factor 4	charged multivesicular body protein 2A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm RNA Polymerase II Transcription Regulator Complex	Autophagosome Membrane Kinetochore Chromatin ESCRT III Complex Nucleus Nuclear Envelope Nuclear Pore Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Membrane Membrane Coat Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Protein Binding Protein Domain Specific Binding Phosphatidylcholine Binding
	Biological Process	Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis Blood Circulation Regulation Of Cell Size Animal Organ Morphogenesis Cell Projection Organization Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Cilium Assembly Centriole Assembly Multi-ciliated Epithelial Cell Differentiation	Plasma Membrane Repair Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Membrane Invagination Exit From Mitosis Regulation Of Centrosome Duplication Protein Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Protein Polymerization Protein Homooligomerization Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport Positive Regulation Of Exosomal Secretion Negative Regulation Of Centriole Elongation ESCRT III Complex Disassembly
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry	Budding and maturation of HIV virion Macroautophagy Lysosome Vesicle Biogenesis Pyroptosis Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		35 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK DHX38 FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RECQL RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRIM33 TRRAP USP2 XPO1	22 interacting genes: CHD3 CHMP3 CYP4F2 DOCK8 E2F4 EIF2B5 ITGA5 KERA MAPKAPK3 MITD1 NCOA1 NOL4 SLC25A1 SNCA STAMBP TGFB3 UFD1 USP54 USP8 VPS4A VPS4B ZNF32
Entrez ID		1874	27243
HPRD ID		02806	12520
Ensembl ID		ENSG00000205250	ENSG00000130724
Uniprot IDs		Q16254	M0R1T5 O43633
PDB IDs		1CF7 5TUU	7ZCG 7ZCH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Regulation Of Lipid Kinase Activity Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromatin Positive Regulation Of Metabolic Process Co-SMAD Binding Chromatin Organization DNA Binding Regulation Of Cell Cycle Process IkappaB Kinase Activity Paraxial Mesoderm Morphogenesis Promoter-specific Chromatin Binding R-SMAD Binding Cell Differentiation BHLH Transcription Factor Binding Ubiquitin Protein Ligase Binding Mesoderm Morphogenesis Rb-E2F Complex Chromatin Remodeling Regulation Of Mitotic Cell Cycle	Mitotic Cytokinetic Process Viral Budding Viral Budding Via Host ESCRT Complex Midbody Abscission Cytokinetic Process Multivesicular Body Sorting Pathway Viral Budding From Plasma Membrane K63-linked Deubiquitinase Activity Late Endosome To Lysosome Transport Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Regulation Of Exosomal Secretion Midbody Endosome Organization Nuclear Membrane Reassembly Cytoskeleton-dependent Cytokinesis Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Mitotic Metaphase Chromosome Alignment Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Nuclear Membrane Organization Autophagosome Maturation Viral Process Late Endosome Membrane Positive Regulation Of Secretion Biological Process Involved In Interaction With Host Endosome To Lysosome Transport Metaphase Chromosome Alignment Membrane Assembly ESCRT III Complex Disassembly ESCRT Complex Disassembly Mitotic Cytokinesis ATPase Complex Regulation Of Exocytosis Regulation Of Secretion Chromosome Localization Positive Regulation Of Exocytosis Positive Regulation Of Exosomal Secretion Nuclear Pore Protein Domain Specific Binding Cysteine-type Deubiquitinase Activity Nucleus Organization Protein Deubiquitination
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