E2F3 and MGA

Number of citations of the paper that reports this interaction (PubMedID 12748276)
56

Data Source:
BioGRID (two hybrid)

		E2F3	MGA
Description		E2F transcription factor 3	MAX dimerization protein MGA
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Import Into Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence G2 Phase Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Estimated glomerular filtration rate in non-diabetics ( 31451708) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Metabolite levels ( 23823483) Molybdenum levels ( 26025379) Obesity-related traits ( 23251661) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006)	Feeling nervous ( 29500382) Lung function (FEV1/FVC) ( 28166213 30804560) Mean spheric corpuscular volume ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		26 interacting genes: ATAD2 CCNA2 CCNF CDK3 DNMT3L FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RCAN1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 UCHL5 WNK1 YY1	10 interacting genes: CBX3 E2F1 E2F3 E2F4 H3-4 LSM8 MAX RASGRP1 SMAD1 TULP3
Entrez ID		1871	23269
HPRD ID		02693	19055
Ensembl ID		ENSG00000112242	ENSG00000174197
Uniprot IDs		O00716	A0A994J6L2 Q8IWI9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Chromatin Remodeling G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Organization Rb-E2F Complex Transcription Regulator Complex Cyclin-dependent Protein Kinase Holoenzyme Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Mitotic Cell Cycle Phase Transition Anaphase-promoting Complex Binding Cell Cycle Phase Transition DNA Binding DNA-binding Transcription Factor Binding Positive Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance In Response To DNA Damage Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Ino80 Complex Regulation Of DNA Strand Elongation Response To Hormone Transcription Factor Binding Negative Regulation Of Calcium-mediated Signaling Regulation Of Chromosome Organization	RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity Protein Dimerization Activity Negative Regulation Of Fat Cell Proliferation Transcription Regulator Complex Chromatin Nucleoplasm DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Nuclear Inner Membrane Heterochromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Bone Development Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Homomeric SMAD Protein Complex Myc-Max Complex Mad-Max Complex Bronchus Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Intraciliary Transport Particle A Binding Chromatin Lock Complex Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Lens Fiber Cell Apoptotic Process Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Spermatogonial Cell Division Senescence-associated Heterochromatin Focus Regulation Of Macromolecule Metabolic Process Rb-E2F Complex Anti-Mullerian Hormone Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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