TOR1A and ENPP2

		TOR1A	ENPP2
Description		torsin family 1 member A	ectonucleotide pyrophosphatase/phosphodiesterase 2
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Synaptic Vesicle Endomembrane System Membrane Transport Vesicle Secretory Granule Growth Cone Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Cell Projection Synapse Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Cytoskeletal Protein Binding Hydrolase Activity ATP Hydrolysis Activity Kinesin Binding Identical Protein Binding Unfolded Protein Binding Misfolded Protein Binding ATP-dependent Protein Folding Chaperone	Nucleic Acid Binding Phosphodiesterase I Activity Phosphatidylcholine Lysophospholipase Activity Phospholipase D Activity Scavenger Receptor Activity Calcium Ion Binding Zinc Ion Binding Hydrolase Activity Polysaccharide Binding Metal Ion Binding Alkylglycerophosphoethanolamine Phosphodiesterase Activity
	Biological Process	Protein Deneddylation Protein Folding Response To Oxidative Stress Nuclear Envelope Organization Cell Adhesion Neuron Projection Development Protein Localization To Nucleus ERAD Pathway Wound Healing, Spreading Of Cells Intermediate Filament Cytoskeleton Organization Synaptic Vesicle Transport Synaptic Vesicle Membrane Organization Regulation Of Dopamine Uptake Involved In Synaptic Transmission Nuclear Membrane Organization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Protein Localization To Cell Surface	Lipid Metabolic Process Phospholipid Metabolic Process Chemotaxis Immune Response Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Vesicle-mediated Transport Sphingolipid Catabolic Process Regulation Of Cell Migration Phosphatidylcholine Catabolic Process Cell Motility Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Cargo recognition for clathrin-mediated endocytosis	Vitamin B5 (pantothenate) metabolism
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Prostate cancer (early onset) ( 29892016)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cortical volume ( 32963231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 31562340) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Major depressive episode treated with electroconvulsive therapy ( 33483693) Offspring birth weight ( 31043758)
Interacting Genes		10 interacting genes: ENPP2 KRTAP10-7 LMNA LRRC7 MDFI NOTCH1 PAEP SNCA TOR1AIP2 TOR1B	4 interacting genes: DYRK1A HSPB1 LCOR TOR1A
Entrez ID		1861	5168
HPRD ID		06897	03037
Ensembl ID		ENSG00000136827	ENSG00000136960
Uniprot IDs		B3KPA1 O14656	E7EUF1 Q13822
PDB IDs		5J1S 5J1T 6OIF	4ZG6 4ZG7 4ZG9 4ZGA 5KXA 5M7M 5MHP 8C3O 8C3P
Enriched GO Terms of Interacting Partners?		Protein Localization To Nucleus Protein Localization To Nuclear Envelope Membrane Organization Protein Localization To Organelle Negative Regulation Of Muscle Hypertrophy Cardiac Cell Development Nuclear Membrane Identical Protein Binding Negative Regulation Of Cardiac Muscle Hypertrophy Protein Sequestering Activity Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Negative Regulation Of Exocytosis Coronary Sinus Valve Morphogenesis Enzyme Inhibitor Activity Foregut Morphogenesis Negative Regulation Of Sperm Capacitation Alkylglycerophosphoethanolamine Phosphodiesterase Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Kinesin Binding Endoplasmic Reticulum Organization Protein-containing Complex Localization DNA Double-strand Break Attachment To Nuclear Envelope Regulation Of Cardiac Muscle Hypertrophy Structural Constituent Of Nuclear Lamina Axis Specification Notch Signaling Involved In Heart Development Endocardium Morphogenesis Mitral Valve Formation Positive Regulation Of Aorta Morphogenesis Coronary Vein Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Right Atrium Morphogenesis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Muscle Cell Development Intracellular Protein Localization Regulation Of Locomotion Import Into Nucleus Protein Import Into Nucleus MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation	Cytoskeletal Protein Binding Histone H3T45 Kinase Activity Unfolded Protein Binding Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Heterochromatin Formation Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Folding Positive Regulation Of Synaptic Vesicle Recycling Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cytoskeleton Neurofilament Protein Deneddylation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Synaptic Vesicle Membrane Organization Positive Regulation Of Endothelial Cell Chemotaxis Protein Transport Along Microtubule Contractile Muscle Fiber Histone Methyltransferase Binding Identical Protein Binding Misfolded Protein Binding
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